Mechanisms and Novel Therapeutic Approaches for Scarring

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 1976

Special Issue Editor


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Guest Editor
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjiku-ku, Tokyo 160-8582, Japan
Interests: fibroblasts; inflammation; fibrosis; cutaneous wound healing

Special Issue Information

Dear Colleagues,

Scarring can be a significant concern for patients, as it can affect their appearance and self-confidence. While plastic surgeons can perform procedures to minimize the visibility of scars, the complete removal of scars is not always possible. However, advances in medical technology, such as laser devices, cytokines, and cell therapy, have opened up new possibilities for scar treatment. It is crucial that these treatments be based on scientific evidence to ensure their safety and effectiveness. Therefore, the aim of this Special Issue is to delve into the latest therapeutic approaches for scars, examining their mechanisms and exploring innovative solutions to help patients achieve smoother, more aesthetically pleasing skin.

Dr. Noriko Aramaki-Hattori
Guest Editor

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Published Papers (1 paper)

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Research

15 pages, 9482 KiB  
Article
Regeneration of Panniculus Carnosus Muscle in Fetal Mice Is Characterized by the Presence of Actin Cables
by Mariko Hamada, Kento Takaya, Qi Wang, Marika Otaki, Yuka Imbe, Yukari Nakajima, Shigeki Sakai, Keisuke Okabe, Noriko Aramaki-Hattori and Kazuo Kishi
Biomedicines 2023, 11(12), 3350; https://doi.org/10.3390/biomedicines11123350 - 18 Dec 2023
Cited by 1 | Viewed by 1635
Abstract
Mammalian skin, including human and mouse skin, does not regenerate completely after injury; it is repaired, leaving a scar. However, it is known that skin wounds up to a certain stage of embryonic development can regenerate. The mechanism behind the transition from regeneration [...] Read more.
Mammalian skin, including human and mouse skin, does not regenerate completely after injury; it is repaired, leaving a scar. However, it is known that skin wounds up to a certain stage of embryonic development can regenerate. The mechanism behind the transition from regeneration to scar formation is not fully understood. Panniculus carnosus muscle (PCM) is present beneath the dermal fat layer and is a very important tissue for wound contraction. In rodents, PCM is present throughout the body. In humans, on the other hand, it disappears and becomes a shallow fascia on the trunk. Fetal cutaneous wounds, including PCM made until embryonic day 13 (E13), regenerate completely, but not beyond E14. We visualized the previously uncharacterized development of PCM in the fetus and investigated the temporal and spatial changes in PCM at different developmental stages, ranging from full regeneration to non-regeneration. Furthermore, we report that E13 epidermal closure occurs through actin cables, which are bundles of actomyosin formed at wound margins. The wound healing process of PCM suggests that actin cables may also be associated with PCM. Our findings reveal that PCM regenerates through a similar mechanism. Full article
(This article belongs to the Special Issue Mechanisms and Novel Therapeutic Approaches for Scarring)
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