Molecular Regulation of Spermatozoa—Second Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 92
Special Issue Editor
Interests: reproduction; female fertility preservation; male fertility preservation; female infertility; male infertility; oocyte; sperm; embryo; ovarian tissue; spermatogonial stem cell; testicular tissue; reproductive cells and tissues culture; reproductive cells and tissues cryopreservation; apoptosis; oxidative stress; antioxidant therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infertility is a common problem affecting many couples worldwide. In approximately 50% of cases, the male factor is the primary or contributing cause. In most infertile cases, adequate numbers of spermatozoa are produced, and in fact, these numbers are sufficient to induce pregnancy; however, the biological functions such as capacitation, hyperactivation, acrosome reaction, and fertilizing ability of those spermatozoa have been compromised and are considered the most frequent cause of human infertility. A dynamic interplay between spermatozoa and a constantly changing environment is necessary to activate the underlying molecular events and signaling pathways that regulate sperm functions. Various signaling molecules, such as hormones, immune regulatory molecules, neurotransmitters, ions, proteins, growth factors, and free radicals, regulate sperm functions, mainly through post-translational modifications of proteins. Therefore, the deregulation of those interactions can be behind male factor infertility.
For this Special Issue of ”Biomedicines”, we invite you to contribute either an original research article or a review article on the topic “Molecular Regulation of Spermatozoa.” The scope includes in vitro and in vivo research on molecular mechanisms and signaling pathways that regulate spermatozoa function in physiological conditions and under special conditions, such as those causing male infertility or subfertility. Additionally, any paper related to the redox regulation role in sperm function is welcome.
Dr. Atefeh Najafi
Guest Editor
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Keywords
- spermatogenesis
- spermiogenesis
- sperm
- capacitation
- acrosome reaction
- hyperactivation
- fertilization
- male infertility
- antioxidants
- redox regulation
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