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Biomedicines
Special Issues
Pathogenesis and Therapy of Neurovascular Compression Syndromes
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Pathogenesis and Therapy of Neurovascular Compression Syndromes

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 13158

Special Issue Editor

Dr. Bartosz Szmyd

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Guest Editor
Department of Neurosurgery and Neurooncology, Medical University of Lodz, Barlicki University Hospital, Lodz, Poland
Interests: neurosurgery; neuro-oncology; brain tumors; genetic predispostition to cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurovascular compression syndromes are challenging disorders resulting from the compression of cranial nerves at the transition zone. Their exact pathomechanism remains unclear. The most likely chain of events leading to neurovascular compression symptoms is vascular compression in the transition zone → demyelination → nucleus hyperexcitability → symptoms. The proposed Special Issue aims to enhance efforts leading to better insights into the pathogenesis of neurovascular compression syndromes and its possible link to new therapeutic approaches. We encourage authors to submit papers related to the following aspects of pathogenesis/treatment:

  • Anatomical and/or hemodynamical variability;
  • Nerve structure alternations;
  • Nucleus hyperexcitability;
  • Brain white/gray matter changes;
  • Disturbances in ion channels;
  • Inflammatory background;
  • Alerted proteome and biochemical parameters;
  • Other possible aspects of the pathogenesis of neurovascular compression syndromes;
  • Therapeutic approaches.

Dr. Bartosz Szmyd
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurovascular conflicts
  • neurovascular compression syndromes
  • trigeminal neuralgia
  • hemifacial spasm
  • glossopharyngeal neuralgia
  • geniculate neuralgia
  • superior laryngeal neuralgia

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Editorial

Jump to: Research, Review

3 pages, 195 KiB  
Editorial
Pathogenesis and Therapy of Neurovascular Compression Syndromes: An Editorial
by Bartosz Szmyd, Karol Wiśniewski and Dariusz J. Jaskólski
Biomedicines 2024, 12(7), 1486; https://doi.org/10.3390/biomedicines12071486 - 5 Jul 2024
Viewed by 751
Abstract
Neurovascular compression syndromes (NVC) remains a challenging disorders resulting from the compression of cranial nerves at the transition zone [...] Full article
(This article belongs to the Special Issue Pathogenesis and Therapy of Neurovascular Compression Syndromes)

Research

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11 pages, 2378 KiB  
Article
Minimally Invasive Retrosigmoidal Parasterional Burr-Hole Approach: Technique and Neuropathic Pain Amelioration after Microvascular Decompression of the Trigeminal Nerve
by José Damián Carrillo-Ruiz, Juan Camilo Covaleda-Rodríguez, José Armando Díaz-Martínez, Antonio Vallejo-Estrella, José Luis Navarro-Olvera, Francisco Velasco-Campos, Armando Armas-Salazar and Fátima Ximena Cid-Rodríguez
Biomedicines 2023, 11(10), 2707; https://doi.org/10.3390/biomedicines11102707 - 5 Oct 2023
Cited by 1 | Viewed by 1382
Abstract
Background: Trigeminal neuralgia, a common condition in clinical practice, often occurs due to vascular compression caused by aberrant or ectopic arterial or venous vessels. Microvascular decompression through a minimally invasive retrosigmoidal approach has shown high rates of pain control, low complication rates, and [...] Read more.
Background: Trigeminal neuralgia, a common condition in clinical practice, often occurs due to vascular compression caused by aberrant or ectopic arterial or venous vessels. Microvascular decompression through a minimally invasive retrosigmoidal approach has shown high rates of pain control, low complication rates, and excellent therapeutic results. Objective: To describe the surgical technique and clinical outcomes in terms of pain relief after microvascular decompression of the trigeminal nerve through a minimally invasive retrosigmoidal parasterional burr-hole technique. Methods: A group of patients with trigeminal neuralgia refractory to medical management who underwent microvascular decompression were examined. The records of the patients were considered retrospectively (2016–2018), and the outcomes were considered based on the Visual Analogue Scale (VAS) and the Barrow Neurological Institute Pain Scale (BNIPS) added to a technical note of the surgical technique for a minimally invasive retrosigmoidal parasterional burr-hole. Results: Twenty-two patients were evaluated, and clinical assessment after surgical intervention showed a decrease in pain according to the VAS, resulting from an average preoperative state of 9.5 ± 0.37 to a postoperative condition of 1.32 ± 1.28, exhibiting statistically significant changes (p < 0.0001, d = 9.356). On the other hand, in relation to the BNIPS scale, a decrease from an average preoperative status of 4.55 ± 0.25 to a postoperative status at 12 months of 1.73 ± 0.54 was also demonstrated, showing significant changes (p < 0.0001, d = 3.960). Conclusion: Microvascular decompression of the trigeminal nerve through a minimally invasive retrosigmoidal parasterional burr-hole is feasible and can be a safe and effective technique for the management of pain. However, further research employing larger sample sizes and longer follow-up periods is necessary. Full article
(This article belongs to the Special Issue Pathogenesis and Therapy of Neurovascular Compression Syndromes)
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Review

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14 pages, 1316 KiB  
Review
Non-Surgical Treatments of Trigeminal Neuralgia from the Perspective of a Pain Physician: A Narrative Review
by Jin Young Lee, Gil Ho Lee, Seung Hyun Yi, Woo Seog Sim, Bae Wook Kim and Hue Jung Park
Biomedicines 2023, 11(8), 2315; https://doi.org/10.3390/biomedicines11082315 - 21 Aug 2023
Cited by 3 | Viewed by 3864
Abstract
Trigeminal neuralgia (TN) is a unilateral disorder characterized by electric shock-like pain, abrupt onset and termination, and limited to one or more branches of the trigeminal nerve. Various therapeutic modalities for TN have been introduced. We searched for literature indexed in PubMed, Medline, [...] Read more.
Trigeminal neuralgia (TN) is a unilateral disorder characterized by electric shock-like pain, abrupt onset and termination, and limited to one or more branches of the trigeminal nerve. Various therapeutic modalities for TN have been introduced. We searched for literature indexed in PubMed, Medline, and the National Library of Medicine and reviewed all relevant articles on non-surgical treatments for TN. Published studies were reviewed with no restrictions on date; reviews, clinical trials, animal studies, retrospective studies, and cases were included. Carbamazepine and oxcarbazepine are the recommended first-line pharmacotherapies. Interventional treatments should be considered when pharmacotherapy is insufficient or withdrawn because of adverse effects. Full article
(This article belongs to the Special Issue Pathogenesis and Therapy of Neurovascular Compression Syndromes)
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13 pages, 946 KiB  
Review
The Superior Cerebellar Artery: Variability and Clinical Significance
by Mikołaj Malicki, Bartosz M. Szmyd, Ernest J. Bobeff, Filip F. Karuga, Michał M. Piotrowski, Dawid Kościołek, Sora Wanibuchi, Maciej Radek and Dariusz J. Jaskólski
Biomedicines 2023, 11(7), 2009; https://doi.org/10.3390/biomedicines11072009 - 17 Jul 2023
Cited by 9 | Viewed by 6378
Abstract
The superior cerebellar artery (SCA) arises from the distal part of the basilar artery and passes by the oculomotor, trochlear, and trigeminal nerves. SCA is known to play a crucial role in the development of trigeminal neuralgia. However, due to its anatomical variability, [...] Read more.
The superior cerebellar artery (SCA) arises from the distal part of the basilar artery and passes by the oculomotor, trochlear, and trigeminal nerves. SCA is known to play a crucial role in the development of trigeminal neuralgia. However, due to its anatomical variability, it may also trigger other neurovascular compression (NVC), including hemifacial spasm, oculomotor nerve palsy, and ocular neuromyotonia. Additionally, it may be associated with ischemic syndromes and aneurysm development, highlighting its clinical significance. The most common anatomical variations of the SCA include duplication, a single vessel origin from the posterior cerebral artery (PCA), and a common trunk with PCA. Rarely observed variants include bifurcation and origin from the internal carotid artery. Certain anatomical variants such as early bifurcation and caudal course of duplicated SCA trunk may increase the risk of NVC. In this narrative review, we aimed to examine the impact of the anatomical variations of SCA on the NVCs based on papers published in Pubmed, Scopus, and Web of Science databases with a snowballing approach. Our review emphasizes the importance of a thorough understanding of the anatomical variability of SCA to optimize the management of patients with NVCs associated with this artery. Full article
(This article belongs to the Special Issue Pathogenesis and Therapy of Neurovascular Compression Syndromes)
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