STAT3 a Moonlighting Protein: Focus on Its Post-translational Modifications and Protein Interactors
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5992
Special Issue Editors
Interests: stat3; carcinogenesis; transduction signalling pathways; biochemistry OCPs environmental pollutants
Special Issues, Collections and Topics in MDPI journals
Interests: cancer biology; stat3; signal transduction; chemoresistance; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The signal transducer and activator of transcription 3 (STAT3) is a protein with polyhedral activities: it mediates, directly or indirectly, multiple cellular signaling pathways (cytokines of growth factors, hormones and oxidative stress). In addition, it is a key protein in the modulation of metabolism and mitochondrial activity and it is involved in the regulation of microtubule dynamics in the cellular cytoskeleton.
STAT3 activation is crucial in various diseases such as chronic inflammation, cardiovascular and metabolic disorders and cancer. In fact, many scientific publications have assessed the involvement of STAT3, through both its canonical and non-canonical pathways, in all three phases of carcinogenesis: initiation, progression and invasion. STAT3 can be considered a moonlighting protein and its multifaceted activities are mainly exerted via post-translational modifications such as phosphorylation, acetylation, glutathionylation and methylation and interaction with a variety of protein components.
This Special Issue aims to investigate the key role of STAT3, its PTMs and its protein ligands in the modulation of cellular functions. Moreover, this Special Issue should provide a broad and accurate account of STAT3’s cellular and biological functions; we hope that researchers in the field will contribute with research articles, review articles, innovative hypotheses or commentaries on STAT3-related activities and regulations.
Dr. Margherita Eufemi
Guest Editor
Dr. Donatella Romaniello
Co-Guest Editor
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Keywords
- STAT3
- signaling pathways
- post-translational modifications
- interactors
- energy and cellular metabolism
- cancer
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