Novel Insights in Clinical Diagnosis and Therapies of Heart Failure

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 4263

Special Issue Editor


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Guest Editor
Unit of Pharmacology, School of Pharmacy, University of Camerino, 62032 Camerino, Italy
Interests: sports and fitness nutrition; nutrition and metabolic syndrome; diet and cardiovascular diseases; aging and pharmacological responses; fluid electrolyte balance and homeostasis; genetic biomarkers of inflammation and oxidative stress; microbiome; food intolerance testing

Special Issue Information

Dear Colleagues,

Cardiovascular disease is currently amongst the most common causes of morbidity and mortality in developed countries. Cardiovascular disease is a broad term that includes hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease, and cardiomyopathies. Heart failure is thus a highly prevalent condition with a devastating impact on patients’ lives and with increasing heath care costs. To date, there is no single diagnostic test for heart failure. It requires a history, physical examination, and laboratory testing. Therefore, achievements in appropriate diagnosis would be highly important. In order to treat cardiovascular diseases, scientists have focused their efforts on looking at the factors contributing to its etiopathogenesis and also on trying to develop brand new treatments. New insights are also a goal towards the discovery of brand new treatment and novel drugs with fewer underlying untoward effects as well as a rapid progress in gene therapy, which may be one of the options for the treatment of cardiovascular diseases. The aim of this Special Issue is to stimulate interest in developing discoveries and trends for either an early diagnosis or a more effective treatment for heart failure.

Dr. Pierluigi Pompei
Guest Editor

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Keywords

  • cardiovascular diseases
  • heart failure
  • antihypertensive drugs
  • metabolic syndrome
  • aging
  • cardiomyopathies
  • kidney disease

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Published Papers (1 paper)

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Review

20 pages, 622 KiB  
Review
High-Density Lipoprotein-Targeted Therapies for Heart Failure
by Mudit Mishra and Bart De Geest
Biomedicines 2020, 8(12), 620; https://doi.org/10.3390/biomedicines8120620 - 16 Dec 2020
Cited by 8 | Viewed by 3893
Abstract
The main and common constituents of high-density lipoproteins (HDLs) are apolipoprotein A-I, cholesterol, and phospholipids. Biochemical heterogeneity of HDL particles is based on the variable presence of one or more representatives of at least 180 proteins, 200 lipid species, and 20 micro RNAs. [...] Read more.
The main and common constituents of high-density lipoproteins (HDLs) are apolipoprotein A-I, cholesterol, and phospholipids. Biochemical heterogeneity of HDL particles is based on the variable presence of one or more representatives of at least 180 proteins, 200 lipid species, and 20 micro RNAs. HDLs are circulating multimolecular platforms that perform divergent functions whereby the potential of HDL-targeted interventions for treatment of heart failure can be postulated based on its pleiotropic effects. Several murine studies have shown that HDLs exert effects on the myocardium, which are completely independent of any impact on coronary arteries. Overall, HDL-targeted therapies exert a direct positive lusitropic effect on the myocardium, inhibit the development of cardiac hypertrophy, suppress interstitial and perivascular myocardial fibrosis, increase capillary density in the myocardium, and prevent the occurrence of heart failure. In four distinct murine models, HDL-targeted interventions were shown to be a successful treatment for both pre-existing heart failure with reduced ejection fraction (HFrEF) and pre-existing heart failure with preserved ejection fraction (HFrEF). Until now, the effect of HDL-targeted interventions has not been evaluated in randomized clinical trials in heart failure patients. As HFpEF represents an important unmet therapeutic need, this is likely the preferred therapeutic domain for clinical translation. Full article
(This article belongs to the Special Issue Novel Insights in Clinical Diagnosis and Therapies of Heart Failure)
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