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Biomedicines
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Advanced Molecular Research on Pathology, Prevention, Diagnosis and Treatments for...
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Advanced Molecular Research on Pathology, Prevention, Diagnosis and Treatments for Knee Osteoarthritis 2.0

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5728

Special Issue Editors

Dr. Dawid Szwedowski

E-Mail Website1 Website2
Guest Editor
Orthopedic Arthroscopic Surgery International (O.A.S.I.) Bioresearch Foundation, 20-133 Milan, Italy
Interests: shoulder; knee; arthroplasty; sports medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Jai-Hong Cheng

E-Mail Website
Guest Editor
Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Interests: shockwave medicine; translational research; cell therapy; regeneration medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Knee osteoarthritis (OA) is a common disease caused by degeneration or trauma in joints that contributes to inflammation in the synovium, articular cartilage, and subchondral bone. Pathological changes are observed in knee OA, including synovitis, loss of extracellular matrix in the articular cartilage, chondrocyte death, tissue fibrosis, and cyst and osteophyte formation. Knee pain is a major symptom of OA that bothers people of all ages on a daily basis. There are also many other significant symptoms of knee OA, including swelling, stiffness, creaking joints, and difficulty in moving, which affect patients every day. The molecular mechanism of knee OA still needs to be explored further through clinical and preclinical studies. Determining how to identify, discover, and treat problems linked to knee OA are topics of concern and challenges for scientists around the world. Therefore, advances in molecular research in the pathology, prevention, diagnosis, and treatment of knee OA are within the scope of this Special Issue. Summaries of new findings, concepts, and molecular study directions in the form of review articles are also of interest in the Special Issue.

Dr. Dawid Szwedowski
Dr. Jai-Hong Cheng
Guest Editors

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Keywords

  • knee osteoarthritis
  • signaling pathways
  • biomarkers
  • therapy
  • cytokines
  • growth factors
  • microRNA
  • proteomics
  • epigenomics
  • transcriptomics

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Published Papers (2 papers)

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11 pages, 1389 KiB  
Article
Early Knee Osteoarthritis Classification and Clinical Evolution: A Longitudinal Observational Pilot Study
by Luz Herrero-Manley, Ana Alabajos-Cea, Luis Suso-Martí, Enrique Viosca-Herrero and Isabel Vazquez-Arce
Biomedicines 2023, 11(6), 1670; https://doi.org/10.3390/biomedicines11061670 - 9 Jun 2023
Cited by 2 | Viewed by 1666
Abstract
Knee osteoarthritis (KOA) is one of the main problems of an aging society in terms of incidence, impairment to the quality of daily living (QOL), and economics. The main aim of this study was to verify the usefulness, in practical terms, of applying [...] Read more.
Knee osteoarthritis (KOA) is one of the main problems of an aging society in terms of incidence, impairment to the quality of daily living (QOL), and economics. The main aim of this study was to verify the usefulness, in practical terms, of applying the existing diagnostic criteria of early knee osteoarthritis (EKOA). The secondary objective of this project was to evaluate the clinical progression of healthy subjects (HS) at risk of osteoarthritis and of patients with diagnosed EKOA. A cross-sectional longitudinal pilot study was carried out, in which 105 participants were classified as EKOA patients or HS according to the diagnostic criteria. Measures of disability, pain, and self-reported variables were assessed. Two follow-ups were performed in order to assess the diagnoses and radiological progression, and the clinical progression was evaluated using self-reported measures. Following the current diagnostic criteria, the participants were divided into EKOA and HS. Most of the participants did not present changes in their classification, although some subjects were reclassified as EKOA or HS in the follow-ups which were performed. The current classification criteria for EKOA based on self-reported measures, radiological findings, and clinical conditions such as pain could lead to a misdiagnosis of this process, as fluctuations in the classifications of patients according to their conditions were found during follow up. Full article
(This article belongs to the Special Issue Advanced Molecular Research on Pathology, Prevention, Diagnosis and Treatments for Knee Osteoarthritis 2.0)
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14 pages, 1438 KiB  
Systematic Review
Phonophoresis through Nonsteroidal Anti-Inflammatory Drugs for Knee Osteoarthritis Treatment: Systematic Review and Meta-Analysis
by Francisco Javier Martin-Vega, David Lucena-Anton, Alejandro Galán-Mercant, Veronica Perez-Cabezas, Carlos Luque-Moreno, Maria Jesus Vinolo-Gil and Gloria Gonzalez-Medina
Biomedicines 2022, 10(12), 3254; https://doi.org/10.3390/biomedicines10123254 - 14 Dec 2022
Cited by 2 | Viewed by 3486
Abstract
Knee osteoarthritis (OA) is the most common joint disease. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) by phonophoresis is a therapeutic alternative to relieve pain in inflammatory pathologies. The main aim was to analyze the efficacy of the application of NSAIDs by phonophoresis [...] Read more.
Knee osteoarthritis (OA) is the most common joint disease. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) by phonophoresis is a therapeutic alternative to relieve pain in inflammatory pathologies. The main aim was to analyze the efficacy of the application of NSAIDs by phonophoresis in knee OA. A systematic review and meta-analysis of controlled clinical trials were performed between January and March 2021 in the following databases: Web of Science, Scopus, PubMed, Cinahl, SciELO, and PEDro. The PEDro scale was used to evaluate the level of evidence of the selected studies. The RevMan 5.4 statistical software was used to obtain the meta-analysis. Eight studies were included, of which five were included in the meta-analysis, involving 195 participants. The NSAIDs used through phonophoresis were ibuprofen, piroxicam, diclofenac sodium, diclofenac diethylammonium, ketoprofen, and methyl salicylate. The overall result for pain showed not-conclusive results, but a trend toward significance was found in favor of the phonophoresis group compared to the control group (standardized mean difference (SMD) = −0.92; 95% confidence interval: −1.87–0.02). Favorable results were obtained for physical function (SMD = −1.34; 95% CI: −2.00–0.68). Based on the selected studies, the application of NSAIDs by phonophoresis is effective in relieving the symptoms of knee OA. Future long-term studies are recommended. Full article
(This article belongs to the Special Issue Advanced Molecular Research on Pathology, Prevention, Diagnosis and Treatments for Knee Osteoarthritis 2.0)
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