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Biomedicines
Special Issues
Antioxidant Capacities of Natural Products in Human Disease and Health
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Antioxidant Capacities of Natural Products in Human Disease and Health

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 6472

Special Issue Editors

Dr. Marlene Costa

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Guest Editor
REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal
Interests: antioxidant activity; polyphenols; antioxidants; phenolic compounds; phenolic
Dr. Fátima Paiva-Martins

E-Mail Website
Guest Editor
REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal
Interests: antioxidant activity; polyphenols; antioxidants; phenolic compounds; phenolic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antioxidants play an important role in the inhibition of harmful reactive oxygen and nitrogen species in living organisms.  In the body, antioxidants are believed to counteract oxidative stress by inhibiting the free radical-mediated oxidation of lipids, proteins, sugars, and DNA, which is involved in the pathogenesis of various diseases, such as cardiovascular and neurodegenerative diseases, cancer, and in aging.

Natural compounds with free radical-scavenging capacity have received much attention and are being extensively used as antioxidants to replace synthetic antioxidants, whose use is often associated with possible toxic effects by consumers. On the other hand, the emergence of new functional foods rich in oxidative unstable lipids and antioxidant compounds together with the development of integrated medicine has driven the search for more bioactive antioxidant molecules.

The aim of this Special Issue is to highlight recent advances in antioxidant natural compounds and may include original research articles and reviews on the identification of new molecules, isolation procedures from natural sources and its bioactivity, in vitro and in vivo studies on the antioxidant properties of isolated compounds, structure–bioactive relationships, bioavailability, and their use in the prevention and treatment of human diseases. Contributions from every corner of the natural products field are welcome but must be based on concrete, chemically well-defined compound(s).

Dr. Marlene Costa
Dr. Fátima Paiva-Martins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanism of antioxidant natural compound bioactivity
  • antioxidants as a therapeutic approach
  • strategies combining natural compounds and conventional therapeutic approaches
  • pharmacological evidence (in vitro, in vivo) related to antioxidant activities
  • antioxidant activities and inflammation-related disorders
  • functional foods in prevention of chronic diseases
  • bioavailability of antioxidants
  • biomaterials with antioxidant capacity for biomedical application

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Published Papers (2 papers)

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14 pages, 1555 KiB  
Article
Anti-Inflammatory Activity of Olive Oil Polyphenols—The Role of Oleacein and Its Metabolites
by Vânia Costa, Marlene Costa, Romeu António Videira, Paula Branquinho Andrade and Fátima Paiva-Martins
Biomedicines 2022, 10(11), 2990; https://doi.org/10.3390/biomedicines10112990 - 21 Nov 2022
Cited by 15 | Viewed by 2766
Abstract
The anti-inflammatory potential of oleacein, the main polyphenolic compound found in olive oil, and its main metabolites were characterized by their effects on RAW 264.7 macrophages challenged with lipopolysaccharide (LPS), and by their ability to inhibit enzymes of the arachidonic acid metabolism with [...] Read more.
The anti-inflammatory potential of oleacein, the main polyphenolic compound found in olive oil, and its main metabolites were characterized by their effects on RAW 264.7 macrophages challenged with lipopolysaccharide (LPS), and by their ability to inhibit enzymes of the arachidonic acid metabolism with a key role in the synthesis of pro-inflammatory lipid mediators. Oleacein at 12.5 µM significantly decreased the amount of L-citrulline and ●NO generated by LPS-stimulated macrophages. Hydroxytyrosol, hydroxytyrosol acetate and hydroxytyrosol acetate sulfate were also able to reduce the cellular amount of ●NO, although to a lesser extent. In contrast, hydroxytyrosol glucuronide and sulfate did not show detectable effects. Oleacein was also able to inhibit the coupled PLA2 + 5-LOX enzyme system (IC50 = 16.11 µM), as well as the 5-LOX enzyme (IC50 = 45.02 µM). Although with lower activity, both hydroxytyrosol and hydroxytyrosol acetate were also capable of inhibiting these enzymes at a concentration of 100 µM. None of the other tested metabolites showed a capacity to inhibit these enzymes. In contrast, all compounds, including glucuronides and sulfate metabolites, showed a remarkable capacity to inhibit both cyclooxygenase isoforms, COX-1 and COX-2, with IC50 values lower than 3 µM. Therefore, oleacein and its metabolites have the ability to modulate ●NO- and arachidonic acid-dependent inflammatory cascades, contributing to the anti-inflammatory activity associated with olive oil polyphenols. Full article
(This article belongs to the Special Issue Antioxidant Capacities of Natural Products in Human Disease and Health)
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20 pages, 2849 KiB  
Article
Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling
by Máté Nagy-Pénzes, Zoltán Hajnády, Zsolt Regdon, Máté Á. Demény, Katalin Kovács, Tarek El-Hamoly, József Maléth, Péter Hegyi, Csaba Hegedűs and László Virág
Biomedicines 2022, 10(6), 1371; https://doi.org/10.3390/biomedicines10061371 - 10 Jun 2022
Cited by 9 | Viewed by 2990
Abstract
Acute pancreatitis (AP) poses a worldwide challenge due to the growing incidence and its potentially life-threatening course and complications. Specific targeted therapies are not available, prompting the identification of new pathways and novel therapeutic approaches. Flavonoids comprise several groups of biologically active compounds [...] Read more.
Acute pancreatitis (AP) poses a worldwide challenge due to the growing incidence and its potentially life-threatening course and complications. Specific targeted therapies are not available, prompting the identification of new pathways and novel therapeutic approaches. Flavonoids comprise several groups of biologically active compounds with wide-ranging effects. The flavone compound, tricetin (TCT), has not yet been investigated in detail but sporadic reports indicate diverse biological activities. In the current study, we evaluated the potential protective effects of TCT in AP. TCT (30 μM) protected isolated primary murine acinar cells from the cytotoxic effects of cerulein, a cholecystokinin analog peptide. The protective effects of TCT were observed in a general viability assay (calcein ester hydrolysis), in an apoptosis assay (caspase activity), and in necrosis assays (propidium iodide uptake and lactate dehydrogenase release). The effects of TCT were not related to its potential antioxidant effects, as TCT did not protect against H2O2-induced acinar cell death despite possessing radical scavenging activity. Cerulein-induced expression of IL1β, IL6, and matrix metalloproteinase 2 and activation of nuclear factor-κB (NFκB) were reduced by 30 μM TCT. In vivo experiments confirmed the protective effect of TCT in a mouse model of cerulein-induced AP. TCT suppressed edema formation and apoptosis in the pancreas and reduced lipase and amylase levels in the serum. Moreover, TCT inhibited interleukin-1β (IL1β), interleukin-6 (IL6), and tumor necrosis factor-α (TNFα) expression in the pancreas and reduced the activation of the oxidative DNA damage sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1). Our data indicate that TCT can be a potential treatment option for AP. Full article
(This article belongs to the Special Issue Antioxidant Capacities of Natural Products in Human Disease and Health)
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