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Biomolecules
Special Issues
Metabolic Mechanisms in Renal and Cardiovascular Diseases
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Metabolic Mechanisms in Renal and Cardiovascular Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 11550

Special Issue Editors

Prof. Dr. José Pedraza Chaverri

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Guest Editor
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), Mexico City 04510, Mexico
Interests: acute kidney injury; chronic kidney disease; oxidative stress; antioxidants; redox signaling; mitochondrial homeostasis; mitochondrial bioenergetics; natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Laura Gabriela Sánchez-Lozada

E-Mail Website
Guest Editor
Department of Cardio-Renal Physiopathology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
Interests: chronic kidney diseases; cardiovascular diseases
Dr. Omar Emiliano Aparicio Trejo

E-Mail Website
Guest Editor
Department of Cardio-Renal Physiopathology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
Interests: mitochondrial function; bioenergetics; redox signaling; chronic kidney disease; metabolic reprograming and extracelular vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

There is a high interdependence between the physiology of the heart and kidney. Therefore, renal and cardiovascular diseases run parallel, and are becoming a growing worldwide health problem. Recently, alterations in the metabolic pathways that regulate the kidney and the heart function have emerged as crucial mechanisms in developing renal and cardiovascular diseases that result from conditions such as metabolic syndrome, diabetes, and hypertension, among others. Thus, metabolic reprogramming, the impairment of mitochondrial bioenergetics, and the increase in glycolytic flow are strongly linked with pathological processes such as oxidative stress, apoptosis, inflammation, fibrosis, and lipotoxicity associated with cardiac and renal function impairment. Therefore, a more profound comprehension of pathophysiological triggers and the regulation of the metabolic alterations in these diseases will help identify targets for therapeutic interventions and propose preventive measurements to improve or preserve health.

As guest editors, we invite you to contribute to this Special Issue, whose focus will be on the role of metabolic mechanism alteration in renal and cardiovascular diseases as well as in the development of therapeutic interventions against them.

Prof. Dr. José Pedraza Chaverri
Dr. Laura Gabriela Sánchez-Lozada
Dr. Omar Emiliano Aparicio Trejo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic reporgraming in cario-renal damague
  • metabolic syndrome and cardiorenal syndrome
  • oxidative stress and redoz signaling in metabolic disturbances
  • inflamation and fibrosis in metaboic alterations
  • mitochondria impairmemnt in cadiovascular diseases

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Published Papers (2 papers)

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Research

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17 pages, 3422 KiB  
Article
High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome
by Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson and Miguel A. Lanaspa
Biomolecules 2023, 13(5), 780; https://doi.org/10.3390/biom13050780 - 30 Apr 2023
Cited by 8 | Viewed by 3741
Abstract
The presence of obesity and metabolic syndrome is strongly linked with chronic kidney disease (CKD), but the mechanisms responsible for the association are poorly understood. Here, we tested the hypothesis that mice with obesity and metabolic syndrome might have increased susceptibility to CKD [...] Read more.
The presence of obesity and metabolic syndrome is strongly linked with chronic kidney disease (CKD), but the mechanisms responsible for the association are poorly understood. Here, we tested the hypothesis that mice with obesity and metabolic syndrome might have increased susceptibility to CKD from liquid high fructose corn syrup (HFCS) by favoring the absorption and utilization of fructose. We evaluated the pound mouse model of metabolic syndrome to determine if it showed baseline differences in fructose transport and metabolism and whether it was more susceptible to chronic kidney disease when administered HFCS. Pound mice have increased expression of fructose transporter (Glut5) and fructokinase (the limiting enzyme driving fructose metabolism) associated with enhanced fructose absorption. Pound mice receiving HFCS rapidly develop CKD with increased mortality rates associated with intrarenal mitochondria loss and oxidative stress. In pound mice lacking fructokinase, the effect of HFCS to cause CKD and early mortality was aborted, associated with reductions in oxidative stress and fewer mitochondria loss. Obesity and metabolic syndrome show increased susceptibility to fructose-containing sugars and increased risk for CKD and mortality. Lowering added sugar intake may be beneficial in reducing the risk for CKD in subjects with metabolic syndrome. Full article
(This article belongs to the Special Issue Metabolic Mechanisms in Renal and Cardiovascular Diseases)
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Review

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25 pages, 2305 KiB  
Review
Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases
by Masanari Kuwabara, Tomoko Fukuuchi, Yuhei Aoki, Einosuke Mizuta, Motoshi Ouchi, Masafumi Kurajoh, Tatsuya Maruhashi, Atsushi Tanaka, Nagisa Morikawa, Kensuke Nishimiya, Naoyuki Akashi, Yoshihiro Tanaka, Naoyuki Otani, Mihoko Morita, Hiroshi Miyata, Tappei Takada, Hiroshi Tsutani, Kazuhide Ogino, Kimiyoshi Ichida, Ichiro Hisatome and Kohtaro Abeadd Show full author list remove Hide full author list
Biomolecules 2023, 13(10), 1519; https://doi.org/10.3390/biom13101519 - 13 Oct 2023
Cited by 19 | Viewed by 7382
Abstract
The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have reported various comorbidities [...] Read more.
The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have reported various comorbidities linked to hyperuricemia or gout, the range of these associations is extensive. This review article focuses on the relationship between uric acid and thirteen specific domains: transporters, genetic factors, diet, lifestyle, gout, diabetes mellitus, metabolic syndrome, atherosclerosis, hypertension, kidney diseases, cardiovascular diseases, neurological diseases, and malignancies. The present article provides a comprehensive review of recent developments in these areas, compiled by experts from the Young Committee of the Japanese Society of Gout and Uric and Nucleic Acids. The consolidated summary serves to enhance the global comprehension of uric acid-related matters. Full article
(This article belongs to the Special Issue Metabolic Mechanisms in Renal and Cardiovascular Diseases)
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