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Biomolecules
Special Issues
Biomolecules in Development and Diseases of Urogenital System II
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Biomolecules in Development and Diseases of Urogenital System II

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1294

Special Issue Editors

Prof. Dr. Natalija Filipović

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Guest Editor
Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Šoltanska 2, 21000 Split, Croatia
Interests: microvascular and macrovascular complications of diabetes; diabetic nephropathy; renal physiology and pathology; gene expression during embryonic and foetal development; kidneys and urinary system
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Katarina Vukojević

E-Mail Website
Guest Editor
Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Šoltanska 2, 21000 Split, Croatia
Interests: kidney development; congenital anomalies of kidney; next-generation sequencing; chronic kidney diseases; precision medicine; diabetic nephropathy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of the Special Issue “Biomolecules in Development and Diseases of Urogenital System II”.

Basic morphological analyses have a long tradition and continue to provide us with useful information about various biomolecules, enabling us to understand the pathways that underlie the normal development of the urogenital system, as well as the associated pathological changes. For the last three decades, we have been in the era of molecular biology, but it should be emphasized that morphology is still dominant in terms of the distinction between normal versus abnormal development, and the different pathologies of the urogenital system. Moreover, the expression of different biomolecules in some urogenital disorders provides prognostic utility that is captured by morphology. However, there remains the need to identify new biomolecules in the development and diseases of the urogenital system beyond morphology. Accordingly, similar basic processes and genes may be involved in the development and diseases of the urogenital system, with the major difference being that all these processes are tremendously well arranged during normal development. This exciting concept suggests that the underlying key technology, along with comparative studies in development and diseases, may provide unique insights into the link between normal differentiation and pathology. This Special Issue on biomolecules in the development and diseases of the urogenital system should emphasize the importance of a translational approach, which could transform the discovery of biomolecules in the laboratory into innovative diagnostic tools and therapeutic treatments in the field of the development and diseases of the urogenital system.

Prof. Dr. Natalija Filipović
Prof. Dr. Katarina Vukojević
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • development
  • disease
  • urogenital system
  • morphology
  • biomolecules

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Published Papers (1 paper)

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9 pages, 923 KiB  
Brief Report
Loss-of-Imprinting of HM13 Leads to Poor Prognosis in Clear Cell Renal Cell Carcinoma
by Floris Voorthuijzen, Cedric Stroobandt, Wim Van Criekinge, Tine Goovaerts and Tim De Meyer
Biomolecules 2024, 14(8), 936; https://doi.org/10.3390/biom14080936 - 2 Aug 2024
Viewed by 969
Abstract
Genomic imprinting refers to the epigenetic silencing of one of both alleles in a parent-of-origin-specific manner, particularly in genes regulating growth and development. Impaired genomic imprinting leading to the activation of the silenced allele, also called canonical loss-of-imprinting (LOI), is considered an early [...] Read more.
Genomic imprinting refers to the epigenetic silencing of one of both alleles in a parent-of-origin-specific manner, particularly in genes regulating growth and development. Impaired genomic imprinting leading to the activation of the silenced allele, also called canonical loss-of-imprinting (LOI), is considered an early factor in oncogenesis. As LOI studies in clear cell renal cell carcinoma (ccRCC) are limited to IGF2, we performed a genome-wide analysis in 128 kidney normal solid tissue and 240 stage 1 ccRCC samples (TCGA RNA-seq data) to screen for canonical LOI in early oncogenesis. In ccRCC, we observed LOI (adj. p = 2.74 × 10−3) of HM13 (Histocompatibility Minor 13), a signal peptide peptidase involved in epitope generation. HM13 LOI samples featured HM13 overexpression, both compared to normal solid tissues (p = 3.00 × 10−7) and non-LOI (p = 1.27 × 10−2) samples. Upon adjustment for age and sex, HM13 expression was significantly associated with poor survival (p = 7.10 × 10−5). Moreover, HM13 overexpression consistently exacerbated with increasing tumor stage (p = 2.90 × 10−8). For IGF2, LOI was observed in normal solid tissues, but the prevalence did not increase in cancer. In conclusion, HM13 LOI is an early event in ccRCC, causing overexpression leading to poor prognosis. Full article
(This article belongs to the Special Issue Biomolecules in Development and Diseases of Urogenital System II)
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