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Biomolecules
Special Issues
The Role of Histone Modification in Cancer Development
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The Role of Histone Modification in Cancer Development

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5845

Special Issue Editor

Dr. Kyunghwan Kim

E-Mail Website
Guest Editor
Department of Biology, Chungbuk National University, Chungbuk 28644, Republic of Korea
Interests: histone cleavage; histone modification; gene regulation; cell fate
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Histone modification plays a vital role in regulating gene expression, and the dysregulation of histones has been implicated in the development and progression of many diseases, including cancer. This Special Issue seeks to explore the latest advances on the role of histone modification in cancer development, with a particular emphasis on its impact on gene regulation. We welcome original research articles and reviews that investigate this topic, and we encourage submissions that provide insight into the molecular mechanisms by which histone modification contributes to cancer pathogenesis.

Dr. Kyunghwan Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • histone modification
  • gene regulation
  • cancer development

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Published Papers (1 paper)

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Review

30 pages, 1677 KiB  
Review
MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications
by Joanna Szczepanek and Andrzej Tretyn
Biomolecules 2023, 13(11), 1590; https://doi.org/10.3390/biom13111590 - 28 Oct 2023
Cited by 7 | Viewed by 5481
Abstract
In the past decade, significant advances in molecular research have provided a deeper understanding of the intricate regulatory mechanisms involved in carcinogenesis. MicroRNAs, short non-coding RNA sequences, exert substantial influence on gene expression by repressing translation or inducing mRNA degradation. In the context [...] Read more.
In the past decade, significant advances in molecular research have provided a deeper understanding of the intricate regulatory mechanisms involved in carcinogenesis. MicroRNAs, short non-coding RNA sequences, exert substantial influence on gene expression by repressing translation or inducing mRNA degradation. In the context of cancer, miRNA dysregulation is prevalent and closely associated with various stages of carcinogenesis, including initiation, progression, and metastasis. One crucial aspect of the cancer phenotype is the activity of histone-modifying enzymes that govern chromatin accessibility for transcription factors, thus impacting gene expression. Recent studies have revealed that miRNAs play a significant role in modulating these histone-modifying enzymes, leading to significant implications for genes related to proliferation, differentiation, and apoptosis in cancer cells. This article provides an overview of current research on the mechanisms by which miRNAs regulate the activity of histone-modifying enzymes in the context of cancer. Both direct and indirect mechanisms through which miRNAs influence enzyme expression are discussed. Additionally, potential therapeutic implications arising from miRNA manipulation to selectively impact histone-modifying enzyme activity are presented. The insights from this analysis hold significant therapeutic promise, suggesting the utility of miRNAs as tools for the precise regulation of chromatin-related processes and gene expression. A contemporary focus on molecular regulatory mechanisms opens therapeutic pathways that can effectively influence the control of tumor cell growth and dissemination. Full article
(This article belongs to the Special Issue The Role of Histone Modification in Cancer Development)
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