Cell Senescence in Musculoskeletal Pathology and Associated Pain
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 8628
Special Issue Editors
Interests: senescence; intervertebral disc (IVD) degeneration; IVD regeneration; mechanobiology; pain; osteoarthritis; aging; cancer; molecular markers of degeneration; markers of early disc degeneration and osteoarthritis; low back pain; scoliosis; apoptosis; inflammation; SASP factors; senolytics; senomorphics, natural senolytics; senescence-associated pathways; mechanisms of cellular senescence; extracellular matrix composition in normal and pathophysiological conditions; novel therapeutic interventions for degenerative and painful IVD degeneration
Interests: cell and molecular biology; pharmacology; senescence; intervertebral disc degeneration; low back pain; senotherapeutics; scRNA sequencing; natural compounds; drug development; neuroscience; cancer biology
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Special Issue Information
Dear Colleagues,
The Special Issue “Cell Senescence in Musculoskeletal Pathology and Associated Pain” is being prepared for the journal Biomolecules.
There is growing recognition that senescent cells accumulate during connective tissue ageing and degeneration, where they contribute directly to musculoskeletal disorders. They accumulate due to successive shortening of telomere length during replicative cycles or prematurely due to stressors, including DNA damaging agents, oxidative stress, mitochondrial dysfunction, load-induced injury, and disruption of epigenetic regulation. Stress-induced premature senescence is prominent in degenerating musculoskeletal disease even in younger individuals under painful conditions. Senescent cells are resistant to apoptosis and, in addition to changes in their replicative status, release an array of inflammatory cytokines, chemokines, and proteases collectively known as the senescence-associated secretory phenotype (SASP). The inflammatory environment triggered by senescent cells prevents adjacent cells from maintaining tissue homeostasis, and it is proposed to induce senescence in a paracrine manner, thus exacerbating tissue deterioration. All senescent cells share these general features, but there are distinct differences in SASP and in anti-apoptotic pathways linked to cell type, species, and the inducer of senescence. Their functional role in connective tissue homeostasis has sparked interest in researching the complex pathways and intrinsic and extrinsic stimuli controlling senescence and in the development of novel treatment options targeting senescent cells. Original manuscripts and reviews addressing aspects of cellular senescence and senotherapeutics for musculoskeletal pathology and associated pain are very welcome for submission to the Special Issue.
This Special Issue aims to collect original research articles and reviews that provide insights into the causes and consequences related to senescent cells in musculoskeletal pathology and associated pain that can be applied toward the development of therapeutic strategies.
Dr. Lisbet Haglund
Dr. Hosni Cherif
Guest Editors
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