Metal Ion Interactions with Neurotrophins
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 528
Special Issue Editor
Interests: molecular basis of aging and neurodegenerative disorders; mitochondrial bioenergetics; signal transduction pathways; roles of nitric oxide synthase; roles of poly (ADP) ribose polymerase (PARP); mechanisms and effects of amyloidogenic processes; effects of pleiotropic molecules (carnosine, threalose and derivatives); role of metallostasis; importance of proteostasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The presence of neurotrophic factors and neurotransmitters in the surrounding neuronal environment regulates the intracellular molecular machinery that controls neuronal survival, differentiation, and synaptic transmission. Intercellular and intracellular signaling pathways sculpt neuronal circuits during brain development and regulate adaptive neuroplasticity, as well as cell survival during the entire life. Hence, dysregulation of neurotrophins signaling has been associated with several neurodegenerative disorders and age-related pathologic conditions in which metal ion homeostasis is also typically deranged. The normal consequence of this overlap is the growing evidence of the modulatory effects of various metal ions on critical roles of neurotrophic factors.
Metal ions, particularly copper, zinc, and iron, have indeed been correlated with either functional or dysfunctional neuronal outcomes. They can interfere/participate with specific receptor-mediated signaling pathways or modulate the properties of the proteins through direct interaction. In addition, metal ion availability through a well-organized intracellular/extracellular trafficking can affect a plethora of enzymes involved in pro-neurotrophins processing and, in turn, can regulate the secretion of mature forms or increase their degradation. Several other functions of trophic factors, ranging from neuronal differentiation to neurotransmitter release from synaptosomes, can be related to a still unknown variety of effects mediated by metal ions. Thus, further efforts to analyze the contribution of metals to the role of neurotrophins to guarantee neuronal physiology are still warranted.
We cordially welcome you to join us in this endeavor. Comprehensive reviews or original research articles is most welcome. We look forward to reading your contributions.
Prof. Vincenzo Giuseppe Nicoletti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurotrophins;
- copper;
- zinc;
- metal ions–synaptic plasticity;
- neurodegeneration;
- neuronal differentiation;
- neuroregeneration;
- neuronal differentiation.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
