Lipid Remodeling, Trafficking, and Ferroptosis: A Programmed Fatty Death
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 525
Special Issue Editors
Interests: lipid metabolism; lipogenesis; lipidomics; hepatocellular carcinoma; anthracyclines; ferroptosis
Special Issues, Collections and Topics in MDPI journals
Interests: inflammation; innate immunity; lipid mediators; phospholipases; lipins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The modulation of ferroptosis is emerging as a promising tool to induce this programmed cell death and treat different pathophysiological conditions, such as cancer and inflammatory diseases. In ferroptosis, the peroxidation of polyunsaturated fatty acids (PUFAs) wreaks havoc on the cell membranes. Beyond the global content of PUFAs in the cell, the remodeling and trafficking of PUFAs are regulated by specific enzymes (e.g., phospholipases and acyltransferases). Consequently, the regulation and metabolism of PUFAs are key players in the sensitization to ferroptosis. In contrast to PUFAs, other lipids may quench ferroptosis. Hence, in a holistic view, the regulation of the lipidome may modulate the sensitivity of cells to ferroptosis. In conclusion, the characterization of the lipidome is preferred for a better understanding of ferroptosis.
Considering this context, in this Special Issue we welcome original and review manuscripts with new perspectives on the role of the lipidome in ferroptosis. Studies about the role of phospholipases, acyltransferases, and lipoxygenases on ferroptosis are particularly welcome.
We look forward to receiving your contributions.
Dr. David Balgoma
Prof. Dr. Jesús Balsinde
Guest Editors
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Keywords
- ferroptosis
- lipidome
- lipidomics
- phospholipases
- acyltransferases
- lipoxygenases
- lipid peroxidation
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