Natural Products in Chemo- or Hormone Therapy
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5126
Special Issue Editor
Interests: cancer chemoprevention and therapy; anti-cancer phytochemicals; combination treatment; mechanistic study; biomarker/target identification
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chemo- and hormone therapy represent the two main treatments for advanced stages of most types of cancer. However, the clinical success of chemo- and hormone therapeutics is commonly limited by intrinsic or acquired drug resistance, as well as their side effects. Due to the complexity and heterogeneity in cancer genetics, it may be necessary to target multiple signaling pathways within a cancer in order to achieve durable control of the cancer. Given that chemo- and hormone therapy drugs typically have sole or few molecular targets, combinations of these drugs have been widely tested and many have shown encouraging outcomes in enhancing therapeutic effects. Nevertheless, increased toxicity associated with drug–drug combinations is a considerable challenge.
Many natural products, particularly phytochemicals, have drawn increasing interest for their potential to be non-toxic anticancer agents. Natural products are typically able to target multiple signaling molecules and cellular events, promising systemic and durable control of cancer. However, the potency of their targeting activities is usually moderate, as indicated by their relatively high-effective doses as compared to that of drugs. In addition, the bioavailability of most natural compounds is relatively low, and, as a result, their effective doses as needed in vitro can barely be achieved in vivo by oral consumption at safe dose levels.
A combination of natural compounds with chemo- and/or hormone therapy seems to be a promising strategy to overcome the disadvantages of both to achieve a synergistic effect, which indeed has been observed in many previous preclinical studies. This Special Issue aims to facilitate the advancement of this research area by broadcasting the latest findings from mechanistic studies, translational studies, and clinical trial studies. Both research and review articles will be considered.
Dr. Piwen Wang
Guest Editor
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Keywords
- natural compounds
- chemotherapy
- hormone therapy
- cancer
- phytochemicals
- combination
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