Advanced Lab-on-Chip and Micro-systems for Manipulation and Bio-Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 6798

Special Issue Editors

Liaoning Key Laboratory of Marine Sensing and Intelligent Detection, Department of Information Science and Technology, Dalian Maritime University, Dalian 116026, China
Interests: dielectrophoresis; microfluidics and nanofluidics; lab-on-chip; microplastics; soft materials and interfaces; biosensor; particle manipulation and separation; biological cell characterization
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Guest Editor
Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
Interests: microfluidics; micro/nano-fabrication; smart materials; surface modification; biomimetic sensors and systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

To achieve the precise manipulation and detection of micro- and nanotargets, LOC micro-systems provide promising options due to their applications in mechanical, medical, biological, and environmental fields. In all these areas, the adoption of microfluidic devices transforms the efficiency of the reactive process or assay and analytical throughput. For biological and chemical applications, there is great interest in micro/nano-structured channel systems and micro/nano-patterned surfaces. So-called microfluidic devices offer great prospects for carrying out biochemical reactions, as well as successive separation and analysis of the reaction products on one chip. In this Special Issue, entitled “Advanced lab-on-chip and micro-systems for manipulation and detection”, we seek to showcase research papers, communications, and review articles that focus on novel methodological developments by using advanced microfluidic systems for sampling and detection, with particular interest being paid to techniques for the manipulation, separation, characterization, and identification of micro-targets. Based on their ability to perform complex experimental workflows in a rapid, efficient, and robust fashion, the platforms are favorable for defined biological and chemical applications.

Dr. Kai Zhao
Dr. Kaihuan Zhang
Guest Editors

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Keywords

  • microfluidics
  • LOC devices
  • dielectrophoretic
  • microfabrication
  • target manipulation
  • signal detection
  • resolution and throughput

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Published Papers (1 paper)

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Review

37 pages, 7820 KiB  
Review
Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells
by Junzhu Yao, Kai Zhao, Jia Lou and Kaihuan Zhang
Biosensors 2024, 14(9), 417; https://doi.org/10.3390/bios14090417 - 27 Aug 2024
Viewed by 4077
Abstract
Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable progress [...] Read more.
Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable progress in the field of microfluidics, and it has gradually transitioned from laboratory-scale research to high-throughput manipulation in practical applications. This paper reviews the recent advances in dielectric manipulation and separation of microparticles and biological cells and discusses in detail the design of chip structures for the two main methods, direct current dielectrophoresis (DC-DEP) and alternating current dielectrophoresis (AC-DEP). The working principles, technical implementation details, and other improved designs of electrode-based and insulator-based chips are summarized. Functional customization of DEP systems with specific capabilities, including separation, capture, purification, aggregation, and assembly of particles and cells, is then performed. The aim of this paper is to provide new ideas for the design of novel DEP micro/nano platforms with the desired high throughput for further development in practical applications. Full article
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