Portable Optical Biosensor Devices

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 12662

Special Issue Editors


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Guest Editor
Department of Chemistry “Giacomo Ciamician”, University of Bologna, 40126 Bologna, Italy
Interests: optical biosensors; chemiluminescence biosensors; chemosensors; paper-based devices
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemistry “Giacomo Ciamician”, University of Bologna, 40126 Bologna, Italy
Interests: optical biosensors; chemiluminescence biosensors; chemosensors; paper-based devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue is portable optical biosensor devices for specific chemicals and biomolecules analysis in different fields of application, such as healthcare, food quality, and environmental and astrochemical analysis. For that, this Special Issue aims to collect original articles and reviews highlighting research advances, microfabrication and 3D tecnologies, innovative applications, new challenges, and future perspectives of portable optical biosensor devices in important areas such as health, agri-food, and the environment.

Optical biosensors are one of the “fastest and cheapest” biosensors thank to their simplicity and immediacy of manufacture. Disposable (bio)sensors based on optical detection methods (colorimetry, (bio)chemiluminescence, fluorescence, plasmonic resonance, etc) are leading to new possibilities in the selective detection and sensitive quantification of a large number of chemicals and biomolecules. Portable optical biosensor devices, including wax-printed paper-based disposables, lateral flow strips, microfluidics, modified surfaces, and nanomaterials integrated within miniaturized optical detectors such as smartphones, complementary metal–oxide–semiconductor (CMOS) and charge-​coupled device (CCD) cameras, photodiode arrays, etc. are in tune with the growing need for the development of portable devices and for performing rapid and accurate in situ analyses.

The ability to perform accurate and reproducible analyses in real time, quickly using portable and economical devices, with the precision ever closer to the quality guaranteed by expensive and complex laboratory analyses, will facilitate the way we have to monitor health and the environment and prevent diseases and environmental disasters and remedy them immediately.

Dr. Donato Calabria
Dr. Mara Mirasoli
Guest Editors

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Keywords

  • biosensor
  • optical biosensing
  • surface plasmon resonance
  • fluorescence
  • (bio)chemiluminescence
  • colorimetry
  • electrochemiluminescence
  • paper-based analytical device
  • microfluidics
  • smartphone-based biosensor
  • portable devices

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Published Papers (3 papers)

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Research

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9 pages, 2342 KiB  
Communication
Label-Free Cholesteric Liquid Crystal Biosensing Chips for Heme Oxygenase-1 Detection within Cerebrospinal Fluid as an Effective Outcome Indicator for Spontaneous Subarachnoid Hemorrhage
by Hui-Tzung Luh, Yi-Wei Chung, Po-Yi Cho and Yu-Cheng Hsiao
Biosensors 2022, 12(4), 204; https://doi.org/10.3390/bios12040204 - 29 Mar 2022
Cited by 6 | Viewed by 2142
Abstract
A novel device for cholesteric liquid crystal (LC; CLC)-based biosensing chips for detecting heme oxygenase (HO)-1 within the cerebrospinal fluid (CSF) was invented. In the CLC device, the reorientation of the LCs was strongly influenced by the alignment layer surface and adjacent LCs. [...] Read more.
A novel device for cholesteric liquid crystal (LC; CLC)-based biosensing chips for detecting heme oxygenase (HO)-1 within the cerebrospinal fluid (CSF) was invented. In the CLC device, the reorientation of the LCs was strongly influenced by the alignment layer surface and adjacent LCs. When the substrate was coated with the alignment layer, the CLCs oriented homeotropically in a focal conic state. Once HO-1 was immobilized onto the orientation sheet-coated substrate, the CLC changed from a focal conic state to a bright planar state by disrupting the CLCs. The concentration of HO-1 within CSF was shown to be an effective outcome indicator for patients with a spontaneous subarachnoid hemorrhage. We showed that the CLC immunoassaying can be used to measure HO-1 with a lower detection limit of about 10 ng/mL. The linear range was 10 ng/mL to 1 mg/mL. An easy-to-use, rapid-detection, and label-free CLC immunoassay device is proposed. Full article
(This article belongs to the Special Issue Portable Optical Biosensor Devices)
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9 pages, 1309 KiB  
Communication
Portable Waveguide-Based Optical Biosensor
by Philip A. Kocheril, Kiersten D. Lenz, David D. L. Mascareñas, John E. Morales-Garcia, Aaron S. Anderson and Harshini Mukundan
Biosensors 2022, 12(4), 195; https://doi.org/10.3390/bios12040195 - 25 Mar 2022
Cited by 15 | Viewed by 3487
Abstract
Rapid, on-site diagnostics allow for timely intervention and response for warfighter support, environmental monitoring, and global health needs. Portable optical biosensors are being widely pursued as a means of achieving fieldable biosensing due to the potential speed and accuracy of optical detection. We [...] Read more.
Rapid, on-site diagnostics allow for timely intervention and response for warfighter support, environmental monitoring, and global health needs. Portable optical biosensors are being widely pursued as a means of achieving fieldable biosensing due to the potential speed and accuracy of optical detection. We recently developed the portable engineered analytic sensor with automated sampling (PEGASUS) with the goal of developing a fieldable, generalizable biosensing platform. Here, we detail the development of PEGASUS’s sensing hardware and use a test-bed system of identical sensing hardware and software to demonstrate detection of a fluorescent conjugate at 1 nM through biotin-streptavidin chemistry. Full article
(This article belongs to the Special Issue Portable Optical Biosensor Devices)
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Review

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35 pages, 6252 KiB  
Review
Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review
by Muyang Li, Ragini Singh, Yiran Wang, Carlos Marques, Bingyuan Zhang and Santosh Kumar
Biosensors 2022, 12(10), 843; https://doi.org/10.3390/bios12100843 - 8 Oct 2022
Cited by 75 | Viewed by 6102
Abstract
This article presents a concise summary of current advancements in novel nanomaterial-based optical fiber biosensors. The beneficial optical and biological properties of nanomaterials, such as nanoparticle size-dependent signal amplification, plasmon resonance, and charge-transfer capabilities, are widely used in biosensing applications. Due to the [...] Read more.
This article presents a concise summary of current advancements in novel nanomaterial-based optical fiber biosensors. The beneficial optical and biological properties of nanomaterials, such as nanoparticle size-dependent signal amplification, plasmon resonance, and charge-transfer capabilities, are widely used in biosensing applications. Due to the biocompatibility and bioreceptor combination, the nanomaterials enhance the sensitivity, limit of detection, specificity, and response time of sensing probes, as well as the signal-to-noise ratio of fiber optic biosensing platforms. This has established a practical method for improving the performance of fiber optic biosensors. With the aforementioned outstanding nanomaterial properties, the development of fiber optic biosensors has been efficiently promoted. This paper reviews the application of numerous novel nanomaterials in the field of optical fiber biosensing and provides a brief explanation of the fiber sensing mechanism. Full article
(This article belongs to the Special Issue Portable Optical Biosensor Devices)
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