Biosensors Using Quartz Crystal Microbalance

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 2905

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Diagnostics of Laboratory and Methodology of Analisys in Sanity, Dipartimento di Fisica "Ettore Pancini", Università degli Studi di Napoli Federico II, 80138 Naples, Italy
Interests: quartz crystal microbalance; biosensing; immunosensors; localized surface plasmon resonance (LSPR); magnetic biosensors; electrochemical biosensors (CV, EIS); nanoparticles functionalization
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Special Issue Information

Dear Colleagues,

Recently, immunosensors have attracted attention because of their wide range of applications for the detection of various pathogens. Among the commonly used immunosensors, the quartz crystal microbalances (QCM) have featured prominently as an effective tool for the quantification of the amount of antibodies, antigens, or haptens in complex samples with high sensitivity and specificity.

This Special Issue welcomes both reviews and original research articles in the field of quartz crystal microbalances. There is no limit to the chemical and biological aspects by which an gravimetric immunosensor as QCM can be manufactured.

Dr. Bartolomeo Della Ventura
Guest Editor

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Keywords

  • Biosensor
  • Quartz crystal microbalance (QCM)
  • Nanoparticle
  • Label-free sensors
  • Localized Surface Plasmon resonance (LSPR)
  • Immuonsensor
  • Gravimetric immunosensor

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Published Papers (1 paper)

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Research

11 pages, 2133 KiB  
Article
A Portable, Label-Free, Reproducible Quartz Crystal Microbalance Immunochip for the Detection of Zearalenone in Food Samples
by Shengmiao Liu, Xinyu Liu, Qianwen Pan, Zhihan Dai, Mingfei Pan and Shuo Wang
Biosensors 2021, 11(2), 53; https://doi.org/10.3390/bios11020053 - 19 Feb 2021
Cited by 11 | Viewed by 2409
Abstract
This research reports a portable immunochip, based on quartz crystal microbalance (QCM) for label-free, low-cost qualitative detection of zearalenone (ZEN) in food samples. The experimental parameters in the functionalization and working process were evaluated in detail, in order to achieve a high accuracy [...] Read more.
This research reports a portable immunochip, based on quartz crystal microbalance (QCM) for label-free, low-cost qualitative detection of zearalenone (ZEN) in food samples. The experimental parameters in the functionalization and working process were evaluated in detail, in order to achieve a high accuracy and sensitivity. Under optimal conditions, the ZEN concentration at an inhibition ratio of 50% and 15% of the proposed QCM immunochip achieved 3.41 µg L−1 and 0.37 µg L−1, respectively. This portable QCM immunochip also exhibited high specificity, no obvious cross-reaction to five structural analogs of ZEN, and showed other mycotoxins. It could finish the whole qualitative measurement within 30 min, showed good stability during the processes of preparation (SD < 5%, n = 9), storage (frequency response >90%, in PBS at 4 °C for 15 days), and application (frequency response >90% after being reused 6 times). The developed QCM immunochip obtained accurate and repeatable recovery results in ZEN analysis in the chosen food samples (corn, wheat flour, soy sauce, and milk), which had a high correlation (R2 = 0.9844) with that achieved by the HPLC–MS/MS method. In short, this work developed a portable, stable, and reproducible QCM immunochip that could be used for rapid, low-cost, and sensitively measurement of ZEN content in real food samples. Full article
(This article belongs to the Special Issue Biosensors Using Quartz Crystal Microbalance)
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