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Biosensors
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Biosensors Applications Based on Field-Effect Transistors Technologies
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Biosensors Applications Based on Field-Effect Transistors Technologies

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 8886

Special Issue Editor

Dr. Ebrahim Ghafar-Zadeh

E-Mail Website
Guest Editor
Biologically Inspired Sensors and Actuators, Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J 1P3, Canada
Interests: biologically sensors and actuators; CMOS biosensors; integrated microfluidic microelectronic systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Field-effect-transistor (FET) type biosensors have attracted the attention of researchers in academia and industry for various applications, including early detection of COVID-19. Considerable progress has been attained in designing FET devices, such as ion selective field effect transistor (ISFET) and bio-FET, especially for biomedical diagnosis and cell-based assays in the past few decades. The exceptional electronic properties, compactness, and scalability of these novel tools are very desirable for the rapid, label-free, and mass detection of biomolecules. A FET biosensor consists of a FET device coated with a recognition element. A recognition element can be antibody, aptamer, DNA probes or other types of enzymes or proteins.

This Special Issue shall consider the publication of research or review papers that address the challenge of developing FET-based sensors for clinical diagnostics of various diseases such as bacteria-related disease, acute myocardial infarction (AMI), cancer, Alzheimer’s disease (AD), coronavirus disease 2019 (COVID-19), influenza, hepatitis B virus (HBV), and Malaria. This Special Issue will address the design, implementation, modelling, characterization, validation, and/or optimization of FET-based biosensors using standard microelectronic technology, such as complementary metal oxide semiconductors (CMOS) and other microfabrication technologies.

Prof. Dr. Ebrahim Ghafar-Zadeh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • FET
  • CMOS
  • biosensors
  • ISFET
  • BioFET
  • COVID-19
  • infectious diseases

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Published Papers (1 paper)

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Review

50 pages, 9389 KiB  
Review
Recent Advances of Field-Effect Transistor Technology for Infectious Diseases
by Abbas Panahi, Deniz Sadighbayan, Saghi Forouhi and Ebrahim Ghafar-Zadeh
Biosensors 2021, 11(4), 103; https://doi.org/10.3390/bios11040103 - 2 Apr 2021
Cited by 52 | Viewed by 8273
Abstract
Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and [...] Read more.
Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). The COVID-19 pandemic, nevertheless, was an example of the escalated situation in terms of worldwide desperate need for fast, specific and reliable home test PoC devices for the timely screening of huge numbers of people to restrict the disease from further spread. This need spawned a wave of innovative approaches for early detection of COVID-19 antibodies in human swab or blood amongst which the FET biosensing gained much more attention due to their extraordinary LoD down to femtomolar (fM) with the comparatively faster response time. As the FET sensors are promising novel PoC devices with application in early diagnosis of various diseases and especially infectious diseases, in this research, we have reviewed the recent progress on developing FET sensors for infectious diseases diagnosis accompanied with a thorough discussion on the structure of Chem/BioFET sensors and the readout circuitry for output signal processing. This approach would help engineers and biologists to gain enough knowledge to initiate their design for accelerated innovations in response to the need for more efficient management of infectious diseases like COVID-19. Full article
(This article belongs to the Special Issue Biosensors Applications Based on Field-Effect Transistors Technologies)
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