Fluorescent and Luminescent Biosensors: Development and Applications

Dear Colleagues,

Fluorescent and luminescent biosensors are a highly active and interdisciplinary research field. The field has attracted much attention because of its potential to lead to low-cost, rapid, sensitive, and miniaturized bioanalytical devices. In past decades, we have witnessed a tremendous progress in translations of fluorescent and luminescent biosensors from an academic area of research into a most powerful bioanalytical and diagnostic sensor technology. Especially in recent years, this technology development/transition has been reflected in various research efforts to exploit a variety of miniaturized and, in some cases, multiplex analytical formats, such as microfluidics, microarrays, and paper-based analytical devices for quantitative analysis of a whole spectrum of individual ions, small molecules, peptides, proteins, nucleic oligoes, cells, and cellular vesicles. These progresses make fluorescent and luminescent biosensors indispensable tools in the areas from environmental monitoring, to food/agriculture safety, biological/biomedical assays, and medical prognosis and diagnosis. Many of these applications are characterized by their outstanding sensitivity, capable of detecting concentrations in the nano-/picomolar scales, impressive performance in real-time monitor of biological processes, and multiplex capability in diagnostic assays.

This research topic aims to collect recent developments and applications of fluorescent and luminescent sensors as well as highlight prospective directions in the field. We encourage authors to submit both original research and review articles on, but not limited to, the following topics:

Development of fluorescent and luminescent biosensors (molecules, proteins and nanostructure) based on all aspects of molecular spectroscopic mechanisms:

• Fluorescent/luminescent sensors;
• Bioluminescent/chemiluminescent sensors;
• Forster resonance energy transfer (FRET)-based fluorescent sensors;
• Internal charge transfer (ICT)-based fluorescent sensors;
• Aggregation-induced enhancement (AIE)-based fluorescent sensors;
• Anisotropy-based fluorescent sensors;
• Metal enhanced fluorescent sensors;
• Luminescence lifetime-based sensors;

Applications of fluorescent and luminescent biosensors in biologically-related systems:

• Biological applications;
• Medical diagnostics;
• Immunoassays;
• Point-of-care (POC) diagnostics;
• intracellular sensing;
• wearable chemical sensors;
• microbial sensors;
• Food processes and agriculture;
• Environmental monitoring.

Prof. Dr. Wen-Ji Dong
Dr. Anthony Centeno
Dr. Nima Sayyadi
Guest Editors

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