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Biosensors
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Highly Sensitive Biosensors Based on Two-Dimensional Materials
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Highly Sensitive Biosensors Based on Two-Dimensional Materials

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (25 October 2022) | Viewed by 34751

Special Issue Editors

Dr. Aleksey V. Arsenin

E-Mail Website
Guest Editor
Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, 9 Institutsky Lane, 141700 Dolgoprudny, Russia
Interests: novel optical materials; graphene; 2D materials; van der Waals heterostructures; biosensing technology; surface plasmon resonance (SPR) sensors; plasmonic and optical interconnects; functional quantum materials and devices
Prof. Dr. Valentyn S. Volkov

E-Mail Website
Guest Editor
Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia
Interests: graphene; 2D materials and van der Waals heterostructures; novel optical materials; biosensing technology; linear and nonlinear nano-optics; plasmonics (including plasmonic and optical interconnects); scanning near-field optical microscopy; integrated and fiber optics; functional graphene-based devices
Special Issues, Collections and Topics in MDPI journals
Dr. Gleb I. Tselikov

E-Mail Website
Guest Editor
1. Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia
2. Emerging Technologies Research Center, XPANCEO, Dubai Investment Park First, Dubai, United Arab Emirates
Interests: biosensors; metamaterials; transition metal dichalcogenides; nanoparticles; plasmonics and metamaterials for biosensing; theranostics; laser ablation in liquids; Raman spectroscopy; nonlinear optics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is focused on the study and development of highly sensitive biosensors based on two-dimensional (2D) materials. In the past decade, tremendous progress has been made in the study of 2D materials: from h-BN and transition metal dichalcogenides to maxenes/mxenes and 2D perovskites. The exceptional mechanical, electrical, optical, and optoelectronic properties, combined with a variety of chemical properties that can be modified, as well as the large surface areas and one-to-few atom thicknesses of such materials, have made them one of the most promising platforms for the creation of highly sensitive, wearable/flexible, and integrated biosensors. The sensing materials and sensing properties are not limited; the only requirement is that the biosensor design includes 2D materials or van der Waals heterostructures. We welcome contributions on various biosensor designs combining 2D materials and van der Waals heterostructures with traditional sensing platforms such as surface plasmon resonance (SPR), surface-enhanced Raman spectroscopy (SERS), and field-effect transistor-based biosensors. Experimental, theoretical, and numerical simulation results will be considered.

Dr. Aleksey V. Arsenin
Prof. Dr. Valentyn S. Volkov
Dr. Gleb Tselikov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • graphene
  • graphene oxide
  • 2D materials
  • 2D organic–inorganic perovskites
  • 2D carbides and nitrides (MXenes)
  • van der Waals heterostructures
  • biosensing technology
  • surface plasmon resonance (SPR)
  • surface-enhanced Raman spectroscopy (SERS)
  • field-effect transistor (FET) biosensors

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Published Papers (4 papers)

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Research

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11 pages, 1791 KiB  
Article
Optical Anisotropy and Excitons in MoS2 Interfaces for Sensitive Surface Plasmon Resonance Biosensors
by Amir Eghbali, Andrey A. Vyshnevyy, Aleksey V. Arsenin and Valentyn S. Volkov
Biosensors 2022, 12(8), 582; https://doi.org/10.3390/bios12080582 - 29 Jul 2022
Cited by 6 | Viewed by 2343
Abstract
The use of ultra-thin spacer layers above metal has become a popular approach to the enhancement of optical sensitivity and immobilization efficiency of label-free SPR sensors. At the same time, the giant optical anisotropy inherent to transition metal dichalcogenides may significantly affect characteristics [...] Read more.
The use of ultra-thin spacer layers above metal has become a popular approach to the enhancement of optical sensitivity and immobilization efficiency of label-free SPR sensors. At the same time, the giant optical anisotropy inherent to transition metal dichalcogenides may significantly affect characteristics of the studied sensors. Here, we present a systematic study of the optical sensitivity of an SPR biosensor platform with auxiliary layers of MoS2. By performing the analysis in a broad spectral range, we reveal the effect of exciton-driven dielectric response of MoS2 and its anisotropy on the sensitivity characteristics. The excitons are responsible for the decrease in the optimal thickness of MoS2. Furthermore, despite the anisotropy being at record height, it affects the sensitivity only slightly, although the effect becomes stronger in the near-infrared spectral range, where it may lead to considerable change in the optimal design of the biosensor. Full article
(This article belongs to the Special Issue Highly Sensitive Biosensors Based on Two-Dimensional Materials)
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13 pages, 1597 KiB  
Article
Optical Detection of Fat Concentration in Milk Using MXene-Based Surface Plasmon Resonance Structure
by Abdulkarem H. M. Almawgani, Malek G. Daher, Sofyan A. Taya, Mohammad Mashagbeh and Ilhami Colak
Biosensors 2022, 12(7), 535; https://doi.org/10.3390/bios12070535 - 18 Jul 2022
Cited by 42 | Viewed by 2382
Abstract
MXene (Ti3C2Tx) has emerged very recently as an interacting material for surface plasmon resonance (SPR) configuration. It was discovered that Ti3C2Tx can facilitate the adsorption of biomolecules due to its higher binding [...] Read more.
MXene (Ti3C2Tx) has emerged very recently as an interacting material for surface plasmon resonance (SPR) configuration. It was discovered that Ti3C2Tx can facilitate the adsorption of biomolecules due to its higher binding energies, stronger interaction between matter and light, and larger surface area. In this work, a two-dimensional Ti3C2Tx and silicon layer-based SPR refractometric sensor is proposed for the sensitive and fast detection of milk fat concentration due to the high significance of this issue to people all over the world. The proposed SPR structure employs BK7 (BK7 is a designation for the most common Borosilicate Crown glass used for a variety of applications in the visible range) as a coupling prism and silver as a metal layer. The layer thicknesses and the number of Ti3C2Tx sheets are optimized for the highest performance. The highest reached sensitivity is 350 deg./RIU with 50 nm silver and 4 nm silicon with a monolayer of Ti3C2Tx, which is ultra-high sensitivity compared to the latest work that utilizes SPR configuration. The proposed SPR-based sensor’s ultra-high sensitivity makes it more attractive for usage in a variety of biosensing applications. Full article
(This article belongs to the Special Issue Highly Sensitive Biosensors Based on Two-Dimensional Materials)
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13 pages, 3913 KiB  
Communication
SERS Platform Based on Hollow-Core Microstructured Optical Fiber: Technology of UV-Mediated Gold Nanoparticle Growth
by Anastasiia A. Merdalimova, Polina G. Rudakovskaya, Timur I. Ermatov, Alexander S. Smirnov, Sergey S. Kosolobov, Julia S. Skibina, Polina A. Demina, Boris N. Khlebtsov, Alexey M. Yashchenok and Dmitry A. Gorin
Biosensors 2022, 12(1), 19; https://doi.org/10.3390/bios12010019 - 31 Dec 2021
Cited by 5 | Viewed by 3097
Abstract
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for biosensing. However, SERS analysis has several concerns: the signal is limited by a number of molecules and the area of the plasmonic substrate in the laser hotspot, and quantitative analysis in a low-volume droplet [...] Read more.
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for biosensing. However, SERS analysis has several concerns: the signal is limited by a number of molecules and the area of the plasmonic substrate in the laser hotspot, and quantitative analysis in a low-volume droplet is confusing due to the change of concentration during quick drying. The usage of hollow-core microstructured optical fibers (HC-MOFs) is thought to be an effective way to improve SERS sensitivity and limit of detection through the effective irradiation of a small sample volume filling the fiber capillaries. In this paper, we used layer-by-layer assembly as a simple method for the functionalization of fiber capillaries by gold nanoparticles (seeds) with a mean diameter of 8 nm followed by UV-induced chloroauric acid reduction. We also demonstrated a simple and quick technique used for the analysis of the SERS platform formation at every stage through the detection of spectral shifts in the optical transmission of HC-MOFs. The enhancement of the Raman signal of a model analyte Rhodamine 6G was obtained using such type of SERS platform. Thus, a combination of nanostructured gold coating as a SERS-active surface and a hollow-core fiber as a microfluidic channel and a waveguide is perspective for point-of-care medical diagnosis based on liquid biopsy and exhaled air analysis. Full article
(This article belongs to the Special Issue Highly Sensitive Biosensors Based on Two-Dimensional Materials)
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Review

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25 pages, 1166 KiB  
Review
Review: 3-Aminopropyltriethoxysilane (APTES) Deposition Methods on Oxide Surfaces in Solution and Vapor Phases for Biosensing Applications
by Marzhan Sypabekova, Aidan Hagemann, Donggee Rho and Seunghyun Kim
Biosensors 2023, 13(1), 36; https://doi.org/10.3390/bios13010036 - 27 Dec 2022
Cited by 77 | Viewed by 25619
Abstract
Surface functionalization and bioreceptor immobilization are critical processes in developing a highly sensitive and selective biosensor. The silanization process with 3-aminopropyltriethoxysilane (APTES) on oxide surfaces is frequently used for surface functionalization because of beneficial characteristics such as its bifunctional nature and low cost. [...] Read more.
Surface functionalization and bioreceptor immobilization are critical processes in developing a highly sensitive and selective biosensor. The silanization process with 3-aminopropyltriethoxysilane (APTES) on oxide surfaces is frequently used for surface functionalization because of beneficial characteristics such as its bifunctional nature and low cost. Optimizing the deposition process of the APTES layer to obtain a monolayer is crucial to having a stable surface and effectively immobilizing the bioreceptors, which leads to the improved repeatability and sensitivity of the biosensor. This review provides an overview of APTES deposition methods, categorized into the solution-phase and vapor-phase, and a comprehensive summary and guide for creating stable APTES monolayers on oxide surfaces for biosensing applications. A brief explanation of APTES is introduced, and the APTES deposition methods with their pre/post-treatments and characterization results are discussed. Lastly, APTES deposition methods on nanoparticles used for biosensors are briefly described. Full article
(This article belongs to the Special Issue Highly Sensitive Biosensors Based on Two-Dimensional Materials)
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