Cellular and Molecular Mechanisms of Brain Aging
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 715
Special Issue Editors
Interests: neural development; neural stem cells; neurogenesis; aging; gene regulation; morphogens; homeobox genes
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; neuronal cell death and stress; endoplasmic reticulum stress; protein aggregation; misfolded protein diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is associated with cognitive decline and with increased susceptibility to neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, among others. The increasing life expectancy of the human population may result in large numbers of cognitively impaired elderly subjects, with a heavy burden on healthcare systems and huge social and financial challenges. The development of therapeutic approaches to mitigate the effects of aging on brain health and cognitive functions require a comprehensive knowledge of the age-related alterations to brain neuronal networks and the underlying mechanisms, which is still lacking. Furthermore, age-associated neuropathological conditions may involve an enhancement of the mechanisms driving physiological brain aging, a dysregulation of the protective mechanisms active in the aging brain, or both. Therefore, it is crucial to compare the alterations, and the mechanisms, implicated in physiological and pathological brain aging, and to identify common and diverging traits. This Special Issue is focused on the cellular and molecular alterations taking place during physiological and/or pathological brain aging, and on the elucidation of the mechanisms driving them. Submission of both original research articles and of review articles providing a critical discussion of recent progress in the field are welcome. Original research manuscripts providing mechanistic insights based on functional data are preferred, but descriptive studies will also be considered, as long as they do not duplicate previously published work.
Dr. Giuseppe Lupo
Dr. Maria Elena Miranda Banos
Guest Editors
Manuscript Submission Information
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Keywords
- neuronal death
- neuronal dysfunction
- neuroinflammation
- astrocytes
- microglia
- brain vasculature
- gene expression
- protein folding and trafficking
- cell signaling
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