Immune Microenvironment and Immunotherapy in Malignant Brain Tumors
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 25 July 2025 | Viewed by 163
Special Issue Editors
Interests: cancer immunology; immunotherapy brain; spine cancer tumor immunology glioblastoma natural killer T-cells (NKTs)
Special Issue Information
Dear Colleagues,
Immunotherapy has revolutionized cancer treatment in the last decade by demonstrating the power of the immune system to fight against cancer. Although immunotherapy has brought benefits to patients with many cancer types, patients with brain cancer have not yet experienced these benefits. The brain has a unique tissue immune microenvironment, including the blood–brain barrier, unique resident myeloid cells called microglia and neurons. To improve the efficacy of immunotherapy against brain cancer, we need to better understand the immunobiology of these cancers. Emerging data suggest that the interaction of immune cells not only with other immune cells or cancer cells but also with other cell types, such as neurons and blood vessel cells, significantly impacts brain tumor immunity. There are other factors, such as sex and age, that also could have a significant impact on brain tumor immunity. This Special Issue aims to provide comprehensive information on the current understanding of the immune microenvironment of brain cancer, both primary and metastatic, and potential immunotherapeutic approaches.
Dr. Masaki Terabe
Prof. Dr. Mark R. Gilbert
Guest Editors
Manuscript Submission Information
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Keywords
- glioma
- brain metastasis
- primary brain cancer
- tumor immunity
- neuroimmunology
- immune microenvi-ronment
- T cells
- myeloid cells
- cancer neuroscience
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