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Cancers
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Novel Researches on Diagnosis and Treatment of Melanoma
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Novel Researches on Diagnosis and Treatment of Melanoma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2133

Special Issue Editors

Dr. Roberta Giuffrida

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Guest Editor
Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
Interests: dermato-oncology; melanoma; non-melanoma skin cancer; signaling pathways; targeted therapy; artificial intelligence; noninvasive skin imaging; autoimmune/autoinflammatory skin diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Stefania Guida

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Guest Editor
1. School of Medicine, Università Vita-Salute San Raffaele, Milan, Italy
2. Dermatology Clinic, IRCCS San Raffaele Scientific Institute, Milan, Italy
Interests: dermato-oncology; melanoma; non-melanoma skin cancer; noninvasive skin imaging; aesthetic medicine; reflectance confocal microscopy; skin aging
Dr. Caterina Dianzani

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Guest Editor
Campus Biomedico University of Rome, Rome, Italy
Interests: general dermatology; dermatoscopy; inflammatory diseases; aesthetic medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Claudio Conforti

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Guest Editor
Dermatology Clinic of Trieste, Maggiore Hospital, University of Trieste, Trieste, Italy
Interests: dermato-oncology; general dermatology; melanoma; non-melanoma skin cancer; targeted therapy; immunotherapy; noninvasive skin imaging; aesthetic medicine; dermatologic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Melanoma is the deadliest form of skin cancer, and it is thus critical to diagnose and treat it at the earliest stage of its development. In recent decades, enormous progress has been achieved in the diagnosis and treatment of melanoma.

Recent advancements in noninvasive diagnostic strategies have helped to increase sensitivity for the early detection of melanoma and reduce unnecessary surgical procedures, especially in patients with ambiguous melanocytic lesions.

Surgery remains the standard therapy in patients with a localized disease but is not curative for advanced melanoma. In the last ten years, developments in checkpoint inhibition and targeted therapy against melanoma have revolutionized the management of patients with advanced disease.

The aim of this Special Issue is to publish original research articles, reviews, hypotheses, communications and editorial letters to provide new insights into the diagnosis and treatment of melanoma.

Dr. Roberta Giuffrida
Dr. Stefania Guida
Dr. Caterina Dianzani
Dr. Claudio Conforti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melanoma
  • diagnosis
  • treatment
  • nevi
  • noninvasive imaging
  • targeted therapy
  • targeted diagnosis
  • immunotherapy

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Published Papers (2 papers)

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Research

18 pages, 3058 KiB  
Article
Prognostic Role of Clinicopathological Characteristics and Serum Markers in Metastatic Melanoma Patients Treated with BRAF and MEK Inhibitors
by Eszter Anna Janka, Imre Lőrinc Szabó, Sándor Kollár, Tünde Toka-Farkas, Beatrix Ványai, Tünde Várvölgyi, Anikó Kapitány, Hibah Shabu, Andrea Szegedi and Gabriella Emri
Cancers 2024, 16(17), 2981; https://doi.org/10.3390/cancers16172981 - 27 Aug 2024
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Abstract
Prognostic studies can provide important information about disease biology and improve the use of biomarkers to optimize treatment decisions. Methods: A total of 199 patients with advanced melanoma treated with BRAF + MEK inhibitors were included in our single-center retrospective study. We analyzed [...] Read more.
Prognostic studies can provide important information about disease biology and improve the use of biomarkers to optimize treatment decisions. Methods: A total of 199 patients with advanced melanoma treated with BRAF + MEK inhibitors were included in our single-center retrospective study. We analyzed the risk of progression and death using multivariate Cox proportional hazard models. The predictive effect of prognostic factors on progression-free survival (PFS) was evaluated in ROC analysis. Results: We found that primary tumor localization, Clark level, pT category, baseline M stage and baseline serum S100B are independent and significant prognostic factors for PFS. The discriminative power of the combination of these factors was excellent for predicting 18 month PFS (AUC 0.822 [95% CI 0.727; 0.916], p < 0.001). Primary tumor localization on the extremities, Clark level V, baseline M1c stage or M1d stage, and elevated baseline serum S100B and LDH levels were independently and significantly associated with unfavorable overall survival (OS). Conclusion: Baseline M stage and serum S100B appear to be independent prognostic factors for both PFS and OS in melanoma patients treated with BRAF + MEK inhibitors. We newly identified significant and independent prognostic effects of primary tumor localization and Clark level on survival that warrant further investigation. Full article
(This article belongs to the Special Issue Novel Researches on Diagnosis and Treatment of Melanoma)
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10 pages, 241 KiB  
Article
Comparison of Extended Skin Cancer Screening Using a Three-Step Advanced Imaging Programme vs. Standard-of-Care Examination in a High-Risk Melanoma Patient Cohort
by Frank Friedrich Gellrich, Nadia Eberl, Julian Steininger, Friedegund Meier, Stefan Beissert and Sarah Hobelsberger
Cancers 2024, 16(12), 2204; https://doi.org/10.3390/cancers16122204 - 12 Jun 2024
Viewed by 984
Abstract
Modern diagnostic procedures, such as three-dimensional total body photography (3D-TBP), digital dermoscopy (DD), and reflectance confocal microscopy (RCM), can improve melanoma diagnosis, particularly in high-risk patients. This study assessed the benefits of combining these advanced imaging techniques in a three-step programme in managing [...] Read more.
Modern diagnostic procedures, such as three-dimensional total body photography (3D-TBP), digital dermoscopy (DD), and reflectance confocal microscopy (RCM), can improve melanoma diagnosis, particularly in high-risk patients. This study assessed the benefits of combining these advanced imaging techniques in a three-step programme in managing high-risk patients. This study included 410 high-risk melanoma patients who underwent a specialised imaging consultation in addition to their regular skin examinations in outpatient care. At each visit, the patients underwent a 3D-TBP, a DD for suspicious findings, and an RCM for unclear DD findings. The histological findings of excisions initiated based on imaging consultation and outpatient care were compared. Imaging consultation detected sixteen confirmed melanomas (eight invasive and eight in situ) in 39 excised pigmented lesions. Outpatient care examination detected seven confirmed melanomas (one invasive and six in situ) in 163 excised melanocytic lesions. The number needed to excise (NNE) in the imaging consultation was significantly lower than that in the outpatient care (2.4 vs. 23.3). The NNE was 2.6 for DD and 2.3 for RCM. DD, 3D-TBP, or RCM detected melanomas that were not detected by the other imaging methods. The three-step imaging programme improves melanoma detection and reduces the number of unnecessary excisions in high-risk patients. Full article
(This article belongs to the Special Issue Novel Researches on Diagnosis and Treatment of Melanoma)
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