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Cancers
Special Issues
Polyphenols in Cancer Treatment
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Polyphenols in Cancer Treatment

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (9 June 2023) | Viewed by 5738

Special Issue Editors

Dr. Dimiter B. Avtanski

E-Mail Website
Guest Editor
Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, New York, NY 10022, USA
Interests: breast cancer; EMT; obesity; cytokines; inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Sonali Sengupta

E-Mail Website
Guest Editor
Department of Microbiology, Gargi College, University of Delhi, New Delhi, India
Interests: microbiology; compound; polyphenol
Prof. Dr. Marcos Roberto de Oliveira

E-Mail Website
Guest Editor
1. Departamento de Química, Universidade Federal de Mato Grosso (UFMT), Cuiaba, Brazil
2. Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, Brazil
Interests: apoptosis; mitochondria; respiratory chain; antioxidant; redox biology; mitochondrial biogenesis; mitochondrial is research interests include natural compounds; polyphenols; mitochondria-related signaling; oxidative stress; neuroinflammation; neurotoxicology; neurodege; mitochondrial medicine

Special Issue Information

Dear Colleagues, 

Polyphenols are a large family of chemical compounds broadly distributed in nature and characterized by the presence of multiple phenol structures in their molecules. They are mainly synthesized in plants as secondary metabolites to protect against pathogens or ultraviolet light. Naturally derived polyphenols are an integral part of the human diet and have been used in traditional medicine for their pleiotropic (antiseptic, anti-inflammatory, antioxidant, etc.) properties. Many natural polyphenols and their synthetic analogs have been demonstrated to possess anti-carcinogenic activities, such as suppressing cancer cell proliferation, adhesiveness, invasiveness, metastasis, and tumor angiogenesis. They act through the modulation of multiple signaling pathways and the expression of cancer-regulating genes. Moreover, polyphenolic compounds exhibit antioxidant activities affecting the levels of reactive oxygen species (ROS) in cells, thus regulating cell proliferation, survival, and apoptosis.

This Cancers special issue focuses on publishing a broad range of research (both basic and preclinical studies) on the effect of various polyphenolic compounds in cancer prevention, initiation, and progression.

Dr. Dimiter B. Avtanski
Dr. Sonali Sengupta
Prof. Dr. Marcos Roberto de Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • cancer prevention
  • cancer treatment
  • oxidative stress
  • antioxidants

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Published Papers (2 papers)

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Review

31 pages, 2827 KiB  
Review
Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery
by Iliyana Sazdova, Milena Keremidarska-Markova, Daniela Dimitrova, Vadim Mitrokhin, Andre Kamkin, Nikola Hadzi-Petrushev, Jane Bogdanov, Rudolf Schubert, Hristo Gagov, Dimiter Avtanski and Mitko Mladenov
Cancers 2023, 15(22), 5478; https://doi.org/10.3390/cancers15225478 - 20 Nov 2023
Cited by 5 | Viewed by 1832
Abstract
EF24, a synthetic monocarbonyl analog of curcumin, shows significant potential as an anticancer agent with both chemopreventive and chemotherapeutic properties. It exhibits rapid absorption, extensive tissue distribution, and efficient metabolism, ensuring optimal bioavailability and sustained exposure of the target tissues. The ability of [...] Read more.
EF24, a synthetic monocarbonyl analog of curcumin, shows significant potential as an anticancer agent with both chemopreventive and chemotherapeutic properties. It exhibits rapid absorption, extensive tissue distribution, and efficient metabolism, ensuring optimal bioavailability and sustained exposure of the target tissues. The ability of EF24 to penetrate biological barriers and accumulate at tumor sites makes it advantageous for effective cancer treatment. Studies have demonstrated EF24’s remarkable efficacy against various cancers, including breast, lung, prostate, colon, and pancreatic cancer. The unique mechanism of action of EF24 involves modulation of the nuclear factor-kappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways, disrupting cancer-promoting inflammation and oxidative stress. EF24 inhibits tumor growth by inducing cell cycle arrest and apoptosis, mainly through inhibiting the NF-κB pathway and by regulating key genes by modulating microRNA (miRNA) expression or the proteasomal pathway. In summary, EF24 is a promising anticancer compound with a unique mechanism of action that makes it effective against various cancers. Its ability to enhance the effects of conventional therapies, coupled with improvements in drug delivery systems, could make it a valuable asset in cancer treatment. However, addressing its solubility and stability challenges will be crucial for its successful clinical application. Full article
(This article belongs to the Special Issue Polyphenols in Cancer Treatment)
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Graphical abstract

22 pages, 5326 KiB  
Review
Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer
by Salwa Bouabdallah, Amna Al-Maktoum and Amr Amin
Cancers 2023, 15(15), 3900; https://doi.org/10.3390/cancers15153900 - 31 Jul 2023
Cited by 38 | Viewed by 3335
Abstract
Cancer is a global health burden responsible for an exponentially growing number of incidences and mortalities, regardless of the significant advances in its treatment. The identification of the hallmarks of cancer is a major milestone in understanding the mechanisms that drive cancer initiation, [...] Read more.
Cancer is a global health burden responsible for an exponentially growing number of incidences and mortalities, regardless of the significant advances in its treatment. The identification of the hallmarks of cancer is a major milestone in understanding the mechanisms that drive cancer initiation, development, and progression. In the past, the hallmarks of cancer have been targeted to effectively treat various types of cancers. These conventional cancer drugs have shown significant therapeutic efficacy but continue to impose unfavorable side effects on patients. Naturally derived compounds are being tested in the search for alternative anti-cancer drugs. Steroidal saponins are a group of naturally occurring compounds that primarily exist as secondary metabolites in plant species. Recent studies have suggested that steroidal saponins possess significant anti-cancer capabilities. This review aims to summarize the recent findings on steroidal saponins as inhibitors of the hallmarks of cancer and covers key studies published between the years 2014 and 2024. It is reported that steroidal saponins effectively inhibit the hallmarks of cancer, but poor bioavailability and insufficient preclinical studies limit their utilization. Full article
(This article belongs to the Special Issue Polyphenols in Cancer Treatment)
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