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Cancers
Special Issues
Recent Advances in Ovarian Cancer Surgery
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Recent Advances in Ovarian Cancer Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 2966

Special Issue Editor

Dr. Henri Azaïs

E-Mail Website
Guest Editor
1. AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynaecological Oncological and Breast Surgery, Hôpital Européen Georges-Pompidou, 75015 Paris, France
2. INSERM UMR-S 1147, University of Paris Cité, Centre de Recherche des Cordeliers, 75006 Paris, France
3. Institut du Cancer Paris CARPEM, 75006 Paris, France
Interests: gynecological cancers; epithelial ovarian cancer; gynecological surgery; photodynamic therapy; tumor-circulating DNA

Special Issue Information

Dear Colleagues,

Surgery for ovarian cancer, especially at an advanced stage, has evolved over the last few years with the reduction in indications for lymph node dissection, the rise of hyperthermic intraperitoneal chemotherapy (HIPEC) in interval cytoreductive surgery (CRS), and the strengthening of the place for secondary CRS in case of recurrence.  

The quality of surgery remains the main prognostic factor for the survival of patients. Progress must still be made to improve the precision of the interventions, the selection of the patients, and their preparation. Thus, we propose this Special Issue to highlight the expected innovations in ovarian cancer surgery in the era of personalized therapies, timing in an optimized therapeutic sequence, the potential benefits of minimally invasive surgery (laparoscopy or robot-assisted) and HIPEC, the role of fluorescence, or the impact of enhanced rehabilitation in surgery, with the objective that future progress will improve the prognosis of patients, but also their quality of life. 

Dr. Henri Azaïs
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epithelial ovarian cancer
  • hyperthermic intraperitoneal chemotherapy
  • minimally invasive surgery
  • robotic surgery
  • fluorescence guided surgery
  • lymph node dissection
  • enhanced recovery
  • photodynamic therapy

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Published Papers (2 papers)

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12 pages, 5092 KiB  
Article
MIRRORS ICG: Perfusion Assessment Using Indocyanine Green (ICG) Peritoneal Angiography during Robotic Interval Cytoreductive Surgery for Advanced Ovarian Cancer
by Christina Uwins, Agnieszka Michael, Simon S. Skene, Hersha Patel, Patricia Ellis, Jayanta Chatterjee, Anil Tailor and Simon Butler-Manuel
Cancers 2024, 16(15), 2689; https://doi.org/10.3390/cancers16152689 - 29 Jul 2024
Viewed by 1129
Abstract
Indocyanine green (ICG) is a fluorescent dye used for sentinel lymph node assessment and the assessment of perfusion in skin flaps and bowel anastomoses. ICG binds serum proteins and behaves as a macromolecule in the circulation. Tumour tissue has increased vascular permeability and [...] Read more.
Indocyanine green (ICG) is a fluorescent dye used for sentinel lymph node assessment and the assessment of perfusion in skin flaps and bowel anastomoses. ICG binds serum proteins and behaves as a macromolecule in the circulation. Tumour tissue has increased vascular permeability and reduced drainage, causing macromolecules to accumulate within it. MIRRORS ICG is designed to determine whether indocyanine green (ICG) helped identify metastatic deposits in women undergoing robotic interval cytoreductive surgery for advanced-stage (3c+) ovarian cancer. Peritoneal surfaces of the abdominal and pelvic cavity were inspected under white light and near-infrared light (da Vinci Si and Xi Firefly Fluorescence imaging, Intuitive Surgical Inc.) following intravenous injection of 20 mg ICG in sterile water. Visibly abnormal areas were excised and sent to histopathology, noting IGC positivity. In total, 102 biopsies were assessed using ICG. Intravenous ICG assessment following neoadjuvant chemotherapy had a sensitivity of 91.1% (95% CI [82.6–96.4%]), a specificity of 13.0% (95% CI [2.8–33.6%]), a positive predictive value of 78.3% (95% CI [68.4–86.2%]), and a negative predictive value of 30.0% (95% CI [6.7–65.2%]) False-positive samples were seen in 9/20 patients. Psammoma bodies were noted in the histopathology reports of seven of nine of these patients with false-positive results, indicating that a tumour had been present (chemotherapy-treated disease). This study demonstrates the appearance of metastatic peritoneal deposits during robotic cytoreductive surgery following the intravenous administration of ICG in women who have undergone neoadjuvant chemotherapy for stage 3c+ advanced ovarian cancer. A perfusion assessment using indocyanine green (ICG) peritoneal angiography during robotic interval cytoreductive surgery for advanced ovarian cancer did not clinically improve metastatic disease identification in patients with high-volume disease. The use of ICG in patients with excellent response to chemotherapy where few tumour deposits remained shows some promise. The potential of molecular imaging to enhance precision surgery and improve disease identification using the robotic platform is a novel avenue for future research. Full article
(This article belongs to the Special Issue Recent Advances in Ovarian Cancer Surgery)
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15 pages, 1515 KiB  
Systematic Review
Secondary Cytoreductive Surgery in Relapsed Platinum-Sensitive Epithelial Ovarian Cancer: A Systematic Review of Randomized Controlled Trials
by Andrea Svennevik Myhr, Line Bjørge and Cecilie Fredvik Torkildsen
Cancers 2024, 16(14), 2613; https://doi.org/10.3390/cancers16142613 - 22 Jul 2024
Cited by 1 | Viewed by 1233
Abstract
Secondary cytoreductive surgery is a treatment option for relapsed platinum-sensitive epithelial ovarian cancer, but no clear indications are defined for the procedure. This systematic review aims to establish clear indications and compare outcomes versus standard-of-care chemotherapy. We conducted an electronic literature search across [...] Read more.
Secondary cytoreductive surgery is a treatment option for relapsed platinum-sensitive epithelial ovarian cancer, but no clear indications are defined for the procedure. This systematic review aims to establish clear indications and compare outcomes versus standard-of-care chemotherapy. We conducted an electronic literature search across three databases and identified 2033 articles, including three phase 3 randomized controlled trials (RCT). The review adhered to PRISMA 2020 guidelines and was registered in PROSPERO (no. CRD42022379817). Despite varying patient selection methods, surgery plus chemotherapy demonstrated significantly prolonged progression-free survival compared to chemotherapy alone. However, overall survival outcomes were inconsistent: while GOG-0213 did not show extended overall survival, recent studies with stricter defined criteria for surgery (SOC-1 and DESKTOP-III) reported improved overall survival with the addition of surgery. Morbidity and mortality rates were low, with no difference in quality of life between the surgery and no-surgery groups. In conclusion, cytoreductive surgery presents a promising option for recurrent epithelial ovarian cancer treatment. Nonetheless, well-defined selection criteria appear crucial for achieving increased overall survival compared to conventional treatment. Full article
(This article belongs to the Special Issue Recent Advances in Ovarian Cancer Surgery)
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