The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 79
Special Issue Editors
Interests: malignant pleural mesothelioma; lung cancer; molecular pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related death worldwide. Substantial molecular heterogeneity at diagnosis further complicates treatment choices and efficacy. However, recent advancements in molecular characterization, mainly for adenocarcinoma histotype, in addition to a better understanding of the immune context of the tumor, are dramatically changing the course of NSCLC patients. At the same time, emerging data on the efficacy of EGFR-tyrosine kinase inhibitors (EGFR-TKIs) and of immune checkpoint inhibitors (ICIs) for NSCLC showcase the need for comprehensive molecular profiling, including of EGFR mutation and PD-L1 status, to tailor treatment strategies. Research into the effectiveness of target and immune-based therapies is extending from local advanced to early-stage NSCLC, delivering positive outcomes and increasingly expanding the role of surgery in stages otherwise traditionally excluded.
Consequently, this growing knowledge highlights the pressing need for enhanced testing procedures, across early diagnosis to advanced disease, ensuring the best treatment option for each patient in the context of precision medicine. In addition, molecular investigations of lung cancer are warranted to uncover and face resistance mechanisms to therapy and identify new predictive biomarkers.
This Special Issue, involving experts in the field, welcomes original articles, case reports, reviews and metanalyses on current insights and upcoming advances in target therapy and immunotherapy, with particular attention to new developments in biomolecular testing and the role of surgery in NSCLC.
We look forward to receiving your contributions.
Dr. Greta Alì
Dr. Maria Giovanna Mastromarino
Guest Editors
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Keywords
- non-small cell lung cancer
- target therapy
- EGFR-tyrosine kinase inhibitors
- immunotherapy
- immune checkpoint inhibitors
- molecular analysis
- surgery
- precision medicine
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