Role of Mitochondria in Cancer: Past, Present and Future
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 249
Special Issue Editors
Interests: ROS; apoptosis; cancer cell biology; oxidative stress; mitochondrial dynamics
Interests: reactive oxygen species; autophagy; GSH; cell signaling
Interests: adipose tissue biology; metabolism, inflammation; epigenetics; neurodegeneration; cancer metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Transformed cells adapt metabolism to support tumor initiation and progression. In this regard, Warburg interpreted tumor lactate secretion as an indication that the mitochondrial oxidative metabolism was impaired. However, numerous studies have failed to demonstrate defective respiration as a general feature of malignant cells and it is now widely accepted that mitochondrial functions are not suppressed in cancer cells, but rather they are reprogrammed to meet the increased demand of biosynthetic precursors and mitigate the oxidative phosphorylation for limiting harmful ROS production.
Today, we have proof that specific mitochondrial activities directly participate in the process of transformation or support the biological processes that promote tumor growth, invasion, migration, and metastasis.
Understanding the context specificity of malignant cell metabolic preferences could help to define the pathways that are limiting cancer progression. Answering these aspects will provide new insights into cancer biology and can guide a more effective targeting of metabolism for clinical benefit.
We invite authors to contribute to this Special Issue with original research articles and reviews describing how cancer-associated mitochondrial alterations promote cancer development and progression to propose mitochondria as targets for antitumor therapy.
We look forward to receiving your contributions.
Prof. Dr. Maria Rosa Ciriolo
Prof. Dr. Enrico Desideri
Dr. Fabio Ciccarone
Guest Editors
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Keywords
- oxidative stress
- mitophagy
- oxidative phosphorylation
- mitochondrial dynamics
- metabolism
- antitumor therapy
- tumor progression
- cell death
- mitochondrial DNA
- mitohormesis
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