Cancer Drug Discovery and Development Targeting Epigenetics, Metabolism, and DNA Repair
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Drug Development".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 4998
Special Issue Editors
Interests: cancer metabolism; cell death; cancer epigenetics; ubiquitination; insulin signaling
Special Issue Information
Dear Colleagues,
Cancer is a leading cause of mortality worldwide. Over the last 25 years, we have ushered in the era of precision oncology with targeted therapeutics, immunotherapy, and gene therapy. However, the need for prevention, early detection, biomarkers, therapeutics, and medical interventions is still immense and is highlighted by programs like the Cancer Moonshot project. Research on established and emerging cancer hallmarks can provide breakthroughs that will benefit cancer patients.
We are pleased to invite you to submit original research and review articles on drug research and development tackling cancer hallmarks such as epigenetics, deregulated metabolism, genome instability, and the crosstalk between them. There are several FDA-approved drugs on the market that target these hallmarks; however, the field is still in its infancy when it comes to discovering novel targets and developing drugs directed at them.
In this Special Issue, original research articles and reviews are welcome. We are seeking research topics in cancer biology/cancer pharmacology that may include, but are not limited to, the following:
- Discovery and development of novel molecules targeting epigenetics and metabolism in cancer;
- Drug development and synthetic lethal strategies involving epigenetics and DNA damage responses;
- Combination approaches, drug repurposing, and strategies to overcome drug resistance, focusing on cancer epigenetics, metabolism, and DNA repair;
- Mechanistic approaches to targets and drugs acting on cancer epigenetics, metabolism, and DNA repair;
- Target discovery in the field of cancer epigenetics, metabolism, and DNA repair;
- Crosstalk between cancer epigenetics and metabolism and/or epigenetics and DNA repair.
We hope that this Special Issue will highlight and amalgamate novel targets, drug discovery, and development efforts in epigenetics, deregulated metabolism, and DNA repair in cancer. We look forward to receiving your contributions.
Dr. Vikas V. Dukhande
Dr. Aditi Jain
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- apoptosis
- bromodomain proteins
- cancer epigenetics
- cancer metabolism
- DNA methylation
- DNA repair
- epigenetic therapeutics
- histone modifications
- metabolic inhibitors
- Warburg effect
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