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Cancers
Special Issues
Nanobiomaterials for Cancer Early Detection and Therapy
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Nanobiomaterials for Cancer Early Detection and Therapy

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (10 May 2023) | Viewed by 8990

Special Issue Editor

Prof. Dr. Maoquan Chu

E-Mail Website
Guest Editor
School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
Interests: nanoparticles; drugs; living cells or bacteria; targeted delivery; cancer therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Early clinical diagnosis and highly efficient therapy are key factors for saving and prolonging the life of cancer patients by improving the quality of living. Conventional techniques have the drawback of often not being able to identify the presence of cancer at its early stage and also have serious side effects during and after treatment. In recent decades, many novel nanobiomaterials have been developed for the detection of cancer at an early stage and in cancer therapeutics by improving pharmacokinetics or other theranostic levels with reduced toxicity. For instance, the combination of magnetic nanoparticles and gold-plated carbon nanotubes for detecting rare cancer cells; long afterglow nanoparticles-based biosensors for detecting tumor markers; nanozyme-mediated photothermal and/or photodynamic therapy or chemodynamic therapy; and biomimetic nanoparticles, nanoparticle-loaded living cells, or nanoparticle-loaded living bacteria for tumor targeted multimodal therapy have attracted significant researcher attention. To capture recent developments in the interesting area, in this Special Issue, we welcome submissions that will contribute to describing the nanobiomaterials for early detection of cancer and therapy. 

Prof. Dr. Maoquan Chu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanobiosensors
  • magnetic nanoparticles
  • nanozymes
  • biomimetic nanoparticles
  • nanoparticle-loaded bacteria
  • nanoparticle-loaded cells
  • early cancer detection
  • tumor targeted therapy

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Published Papers (3 papers)

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Research

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23 pages, 6150 KiB  
Article
Orthogonal Optimization, Characterization, and In Vitro Anticancer Activity Evaluation of a Hydrogen Peroxide-Responsive and Oxygen-Reserving Nanoemulsion for Hypoxic Tumor Photodynamic Therapy
by Liang Hong, Jianman Wang, Yi Zhou, Guofu Shang, Tao Guo, Hailong Tang, Jiangmin Li, Yali Luo, Xiangyu Zeng, Zhu Zeng and Zuquan Hu
Cancers 2023, 15(5), 1576; https://doi.org/10.3390/cancers15051576 - 3 Mar 2023
Cited by 4 | Viewed by 1978
Abstract
Tumor hypoxia can seriously impede the effectiveness of photodynamic therapy (PDT). To address this issue, two approaches, termed in situ oxygen generation and oxygen delivery, were developed. The in situ oxygen generation method uses catalysts such as catalase to decompose excess H2 [...] Read more.
Tumor hypoxia can seriously impede the effectiveness of photodynamic therapy (PDT). To address this issue, two approaches, termed in situ oxygen generation and oxygen delivery, were developed. The in situ oxygen generation method uses catalysts such as catalase to decompose excess H2O2 produced by tumors. It offers specificity for tumors, but its effectiveness is limited by the low H2O2 concentration often present in tumors. The oxygen delivery strategy relies on the high oxygen solubility of perfluorocarbon, etc., to transport oxygen. It is effective, but lacks tumor specificity. In an effort to integrate the merits of the two approaches, we designed a multifunctional nanoemulsion system named CCIPN and prepared it using a sonication-phase inversion composition–sonication method with orthogonal optimization. CCIPN included catalase, the methyl ester of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me), photosensitizer IR780, and perfluoropolyether. Perfluoropolyether may reserve the oxygen generated by catalase within the same nanoformulation for PDT. CCIPN contained spherical droplets below 100 nm and showed reasonable cytocompatibility. It presented a stronger ability to generate cytotoxic reactive oxygen species and consequently destroy tumor cells upon light irradiation, in comparison with its counterpart without catalase or perfluoropolyether. This study contributes to the design and preparation of oxygen-supplementing PDT nanomaterials. Full article
(This article belongs to the Special Issue Nanobiomaterials for Cancer Early Detection and Therapy)
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20 pages, 8868 KiB  
Article
Mannose and Hyaluronic Acid Dual-Modified Iron Oxide Enhances Neoantigen-Based Peptide Vaccine Therapy by Polarizing Tumor-Associated Macrophages
by Ying Nie, Lu Shi, Yanan Zhang, Yunfei Guo and Hongchen Gu
Cancers 2022, 14(20), 5107; https://doi.org/10.3390/cancers14205107 - 18 Oct 2022
Cited by 12 | Viewed by 2720
Abstract
Neoantigen-based cancer vaccine therapy is a breakthrough in the field of immunotherapy. However, it is difficult for vaccines against neoantigens to overcome the immunosuppressive microenvironment, where tumor-associated macrophages (TAMs) play a significant role. Herein, we report an iron oxide nanoparticle modified with hyaluronic [...] Read more.
Neoantigen-based cancer vaccine therapy is a breakthrough in the field of immunotherapy. However, it is difficult for vaccines against neoantigens to overcome the immunosuppressive microenvironment, where tumor-associated macrophages (TAMs) play a significant role. Herein, we report an iron oxide nanoparticle modified with hyaluronic acid and mannose to reshape the tumor microenvironment by targeting and repolarizing TAMs from protumor M2 to antitumor M1 phenotype. Mannose decoration could confer the nanoparticle-enhanced TAM targeting ability, while hyaluronic acid and iron oxide could repolarize M2-like macrophages both in vitro and in vivo. Combined with antigenic peptides, this nanovaccine could significantly increase the infiltration of CD8+ T cells into tumor tissue and strongly activate dendritic cells in sentinel lymph nodes. Finally, we used the dual-modified nanoparticles to first convert the tumor microenvironment and then the nanovaccine administration in a TC1 tumor model to further enhance efficacy. This strategy inhibited tumor growth and achieved a 40% cure rate in mice (two of five). In summary, this study provides a potent and rationally designed nanoadjuvant to enhance antitumor efficiency and facilitate delivery of neoantigen vaccines by repolarizing TAMs and harmonizing immune cells. Full article
(This article belongs to the Special Issue Nanobiomaterials for Cancer Early Detection and Therapy)
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Review

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22 pages, 1365 KiB  
Review
Targeted Therapy and Immunotherapy for Heterogeneous Breast Cancer
by Xiaolu Sun, Kuai Liu, Shuli Lu, Weina He and Zixiu Du
Cancers 2022, 14(21), 5456; https://doi.org/10.3390/cancers14215456 - 6 Nov 2022
Cited by 14 | Viewed by 3656
Abstract
Breast cancer (BC) is the most common malignancy in women worldwide, and it is a molecularly diverse disease. Heterogeneity can be observed in a wide range of cell types with varying morphologies and behaviors. Molecular classifications are broadly used in clinical diagnosis, including [...] Read more.
Breast cancer (BC) is the most common malignancy in women worldwide, and it is a molecularly diverse disease. Heterogeneity can be observed in a wide range of cell types with varying morphologies and behaviors. Molecular classifications are broadly used in clinical diagnosis, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and breast cancer gene (BRCA) mutations, as indicators of tumor heterogeneity. Treatment strategies differ according to the molecular subtype. Besides the traditional treatments, such as hormone (endocrine) therapy, radiotherapy, and chemotherapy, innovative approaches have accelerated BC treatments, which contain targeted therapies and immunotherapy. Among them, monoclonal antibodies, small-molecule inhibitors and antibody–drug conjugates, and targeted delivery systems are promising armamentarium for breast cancer, while checkpoint inhibitors, CAR T cell therapy, cancer vaccines, and tumor-microenvironment-targeted therapy provide a more comprehensive understanding of breast cancer and could assist in developing new therapeutic strategies. Full article
(This article belongs to the Special Issue Nanobiomaterials for Cancer Early Detection and Therapy)
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