New Insights in the Role of Myeloid-Derived Suppressor Cells (MDSCs) in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 88
Special Issue Editor
Interests: primary myelofibrosis; myeloproliferative neoplasms; vascular endothelial growth factor; immunomodulation; chronic myeloproliferative neoplasms; inflammation; myeloid derived suppressor cells, endothelial cells, myeloid cells
Special Issue Information
Dear Colleagues,
In recent years, myeloid-derived suppressor cells (MDSCs) have attracted increasing interest as major players in modulating tumor onset and progression of cancer. Although the physiopathology of MDSCs is still partially elusive, there is common agreement that these cells contribute to tumors pathogenesis through their immunosuppressive and pro-neoangiogenic activities. In keeping with this notion, previous studies demonstrated that the frequency of circulating MDSCs represents a reliable predictor of a negative outcome and response to therapy both in solid cancers and in hematological malignancies. Therefore, MDSCs could become potential targets for future therapeutic strategies aimed at favoring their differentiation into mature cells or at counteracting their immunosuppressive and neoangiogenic activity or at inhibiting their ability to migrate from the bone marrow (BM) to peripheral organs.
In this Special Issue of Cancers, we welcome original research articles, reviews and perspectives that provide an overview of the most recent advances involving MDSCs in hematological malignancies and solid cancers. Proposed submission topics could include (but are not limited to) the following: (1) autocrine/paracrine mechanisms that link MDSCs and the chronic inflammatory milieu; (2) involvement of MDSCs in neo-angiogenic processes and metastasis propagation; (3) pre-clinical studies on MDSCs as a therapeutic target; (4) study of mechanisms of mobilization MDSCs from the BM into circulation.
Dr. Rita Campanelli
Guest Editor
Manuscript Submission Information
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Keywords
- myeloid-derived suppressor cells
- hematological malignancies
- solid cancers
- inflammation
- angiogenesis
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