Signaling Mechanisms Underlying Gastrointestinal Tract Tumorigenesis

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (1 August 2024) | Viewed by 2938

Special Issue Editor

Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA
Interests: colorectal cancer; iron metabolism; hypoxia signaling; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue seeks to comprehensively explore the current research landscape surrounding the intricate signaling mechanisms underlying tumorigenesis in the gastrointestinal tract. The gastrointestinal system plays a crucial role in various physiological processes, and understanding the aberrant signaling pathways leading to tumorigenesis is of paramount importance for developing effective diagnostic and therapeutic strategies.

Authors are invited to contribute original research, reviews and perspectives on diverse aspects of gastrointestinal tumorigenesis signaling. The Special Issue will encompass discussions on the latest findings, technological advancements and novel therapeutic targets related to signaling pathways implicated in the initiation, progression and metastasis of gastrointestinal tract tumors.

Therefore, the primary aim of this Special Issue is to consolidate knowledge on the molecular intricacies of gastrointestinal tumorigenesis, fostering a deeper understanding of the signaling events that drive cancer development in this vital organ system. By shedding light on these mechanisms, we aim to catalyze advancements in early detection, targeted therapies and personalized medicine for gastrointestinal cancers. Researchers, clinicians and experts in the field are encouraged to contribute their insights to collectively advance our understanding and impact the future of gastrointestinal cancer research and treatment.

Dr. Xiang Xue
Guest Editor

Manuscript Submission Information

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Keywords

  • cell signaling
  • GI
  • cancer
  • initiation
  • progression
  • metastasis
  • early detection
  • targeted therapies
  • personalized medicine

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Published Papers (1 paper)

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Review

43 pages, 1436 KiB  
Review
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer
by Annalisa Bruno, Melania Dovizio, Cristina Milillo, Eleonora Aruffo, Mirko Pesce, Marco Gatta, Piero Chiacchiaretta, Piero Di Carlo and Patrizia Ballerini
Cancers 2024, 16(17), 3079; https://doi.org/10.3390/cancers16173079 - 4 Sep 2024
Cited by 1 | Viewed by 2711
Abstract
Micro- and nano-plastics (MNPLs) can move along the food chain to higher-level organisms including humans. Three significant routes for MNPLs have been reported: ingestion, inhalation, and dermal contact. Accumulating evidence supports the intestinal toxicity of ingested MNPLs and their role as drivers for [...] Read more.
Micro- and nano-plastics (MNPLs) can move along the food chain to higher-level organisms including humans. Three significant routes for MNPLs have been reported: ingestion, inhalation, and dermal contact. Accumulating evidence supports the intestinal toxicity of ingested MNPLs and their role as drivers for increased incidence of colorectal cancer (CRC) in high-risk populations such as inflammatory bowel disease (IBD) patients. However, the mechanisms are largely unknown. In this review, by using the leading scientific publication databases (Web of Science, Google Scholar, Scopus, PubMed, and ScienceDirect), we explored the possible effects and related mechanisms of MNPL exposure on the gut epithelium in healthy conditions and IBD patients. The summarized evidence supports the idea that oral MNPL exposure may contribute to intestinal epithelial damage, thus promoting and sustaining the chronic development of intestinal inflammation, mainly in high-risk populations such as IBD patients. Colonic mucus layer disruption may further facilitate MNPL passage into the bloodstream, thus contributing to the toxic effects of MNPLs on different organ systems and platelet activation, which may, in turn, contribute to the chronic development of inflammation and CRC development. Further exploration of this threat to human health is warranted to reduce potential adverse effects and CRC risk. Full article
(This article belongs to the Special Issue Signaling Mechanisms Underlying Gastrointestinal Tract Tumorigenesis)
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