Metastatic Progression and Tumour Heterogeneity
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 August 2019) | Viewed by 118841
Special Issue Editors
Interests: gastro-intestinal cancers; tumor progression; metastasis; treatment response; tumor heterogeneity; cell adhesion; cell signaling
Special Issue Information
Dear Colleagues,
Intratumoral heterogeneity is one of the biggest current challenges for cancer therapy. However, exciting recent developments in single-cell -omics, cellular tracking, and imaging, alongside the expansion of new tools to study clonal and phenotypic diversity in patient samples—such as PDXs, organoids, and liquid biopsies—enable a deeper understanding of the heterogeneous molecular mechanisms that drive tumor progression and underlie poor treatment outcomes.
These new research approaches have unraveled an unforeseen level of cellular and molecular complexity within tumors. High-throughput sequencing has highlighted the broad inter- and intra-tumoral heterogeneity that exists amongst patient cohorts and across tumor streams, while longitudinal studies indicate that the diversity of malignant cell populations that make up primary tumors and metastases can evolve in space and time. Cancer therapies can also reshape the cellular and molecular profile of tumors, and the elucidation of the mechanisms that drive treatment-induced plasticity, selection, and resistance will inform the design of new combinational therapies.
Furthermore, the cellular and molecular features of the tumor microenvironment, including immune cells, have to be taken into consideration for the understanding of tumor progression. Targeting both tumor cells and tumor microenvironment is also an exciting area of investigation, with new approaches such as immunotherapy now emerging as powerful treatment alternatives. Importantly, the heterogeneity of microenvironmental effectors and signals is still marginally understood and will undoubtedly represent the focus of extensive analyses in the next few years.
Thus, comprehensive and integrated analyses of tumor and microenvironment heterogeneity are essential to both improve the overall diagnosis and treatment of patients with cancer and further progress towards precision medicine. This Special Issue will highlight the state-of-the-art technologies aiming to dissect the heterogeneity of malignant cells and their microenvironment and will cover some of the promising discoveries that are likely to improve cancer patients’ outcome.
Assoc. Prof. Fred Hollande
Dr. Delphine Merino
Guest Editors
Manuscript Submission Information
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Keywords
- Tumor Progression
- Heterogeneity
- Cancer Therapy
- Biopsies
- Microenvironment
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