Neurodevelopmental Disabilities (NDDs): From Cellular and Molecular Mechanisms to Innovative Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 221
Special Issue Editors
Interests: intellectual disability and developmental epileptic encephalopathies; ARX-KDM5C; disease models; convergent transcriptional pathways
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues，
Neurodevelopmental disabilities (NDDs) refer to a range of conditions that affect the development of the brain and central nervous system, leading to impairments in cognitive, social, and motor functions. These disorders, which include conditions such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID), are characterized by abnormalities in neural connectivity and synaptic plasticity. This Special Issue delves into the intricate world of neurodevelopmental disabilities, exploring the underlying cellular and molecular mechanisms that contribute to their development.
NDDs are associated with alterations in neuronal migration, differentiation, and survival. Dysregulation of gene expression, epigenetic modifications, and oxidative stress have also been implicated in the pathogenesis of these disorders. In addition, abnormalities in neurotransmitter systems, particularly dopamine and glutamate, have been observed in individuals with NDDs. Molecular mechanisms underlying NDDs involve complex interactions between genetic and environmental factors. Mutations in genes encoding proteins involved in synaptic function, such as SHANK3 and NLGN4X, have been identified as risk factors for ASD. Environmental exposures, including prenatal infections and toxins, may interact with genetic susceptibility to increase the risk of developing NDDs.
Understanding the cellular and molecular mechanisms of NDDs is crucial for developing targeted therapies and interventions for individuals affected by these disorders. Our Special Issue aims to provide insights for the development of innovative therapies that target these mechanisms at the cellular level, offering hope for improved outcomes for individuals with NDDs.
All types of manuscripts, such as research papers and reviews, are welcome. We look forward to your contributions.
Dr. Maria Giuseppina Miano
Dr. Denise Drongitis
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodevelopmental disorders
- cellular mechanisms
- molecular mechanisms
- genetic factors
- brain plasticity
- innovative therapies
- KDM5C
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
