Updates on the Mechanisms and Therapies of Cardiometabolic Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1065
Special Issue Editor
2. College of Professional Studies, Northeastern University, Boston, MA 02101-02117, USA
Interests: cell and gene therapy; cardiovascular disease; metabolic disease; atherosclerosis; dyslipidemia; animal models; drug discovery and development
Special Issue Information
Dear Colleagues,
Cardio-metabolic disorders that include cardiovascular and metabolic diseases such as diabetes are the leading cause of mortality globally. Almost 70% of patients with diabetes develop atherosclerotic cardiovascular disease (ASCVD). Metabolic pathway derangements lead to dyslipidemia and hyperglycemia and increase the risk of ASCVD by increasing glucose, oxidative stress and proatherogenic lipoproteins. Despite significant progress in targeting lipid and glucose metabolic pathways to develop new therapies for CVD treatment, reducing CVD risk in patients is still challenging. Therefore, examining novel pathways and using advanced technologies offer opportunities to understand cellular mechanisms and help develop CVD therapy.
This Special Issue focuses on the mechanism of metabolic pathways and in vitro/in vivo cellular functions to drive therapeutic approaches. New and novel cell and animal models and the use of antisense, mAbs, gene therapy and gene editing technologies now show potential to target novel pathways and tissues for CVD therapy.
Dr. Rai Ajit K. Srivastava
Guest Editor
Manuscript Submission Information
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Keywords
- cardiovascular disease
- atherosclerosis
- metabolic disease
- hyperlipidemia
- diabetes
- proatherogenic lipoproteins
- drug discovery
- gene therapy/gene editing
- ASO
- mAb
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