Research on T Cells in Skin Inflammatory Disorders

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2294

Special Issue Editors


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Guest Editor
1. Department of Dermatology, School of Medicine, University of California San Diego, San Diego, CA, USA
2. Dermatology Section, Department of Medicine, VA San Diego Health System, San Diego, CA, USA
Interests: T cell malignancies; lymphoma; epigenetic; biomarker; immune microenvironment; DNA methylation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Dermatology, Henry Ford Health, Detroit, MI, USA
2. Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA
Interests: skin

Special Issue Information

Dear Colleagues,

The skin is a complex organ that provides critical roles in immune surveillance. T cells are critical cells that contribute to the tissue microenvironment in the regulation of an effective immune response.  Recent research has led to illuminating the heterogenous nature of T cell populations, with the identification of novel T cell subsets defined by cytokine expression that contributes to unique function in immunoregulation.  The well-orchestrated reaction of a normal immune response can at times deviate along an abnormal path, with dysregulation of T cells’ function, leading to a number of heterogenous inflammatory and neoplastic T cell proliferative diseases. The spectrum of abnormality in T cells in the skin is diverse.  Dissecting normal T cell function and how these regulatory pathways run amok is important to understanding the pathogenesis of skin disease.  The advances have shed insight into the role of T cells in immune skin diseases such as atopic dermatitis, psoriasis, vitiligo, hidradenitis suppurative, connective tissue skin disease, as well as malignancies of T cells.  Confirming the critical participation of T cells in skin disease has enabled the development of novel drugs that can affect T cell function with a dramatic impact on disease and improvement in patients quality of life.  For this Special Issue, we invite authors to submit original articles or reviews that discuss insights into the role of T cells in normal immunity as well as in skin diseases, and therapeutics targeting T cells.

Dr. Henry K. Wong
Dr. Qing-Sheng Mi
Guest Editors

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Keywords

  • T cell
  • vitiligo
  • atopic dermatitis
  • T cell lymphoma

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Published Papers (1 paper)

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Review

21 pages, 1064 KiB  
Review
IL-22 in Atopic Dermatitis
by Julia Laska, Maciej Tota, Julia Łacwik, Łukasz Sędek and Krzysztof Gomułka
Cells 2024, 13(16), 1398; https://doi.org/10.3390/cells13161398 - 22 Aug 2024
Viewed by 2031
Abstract
Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin condition characterized by a multifaceted pathophysiology that gives rise to diverse clinical manifestations. The management of AD remains challenging due to the suboptimal efficacy of existing treatment options. Nonetheless, recent progress in elucidating [...] Read more.
Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin condition characterized by a multifaceted pathophysiology that gives rise to diverse clinical manifestations. The management of AD remains challenging due to the suboptimal efficacy of existing treatment options. Nonetheless, recent progress in elucidating the underlying mechanisms of the disease has facilitated the identification of new potential therapeutic targets and promising drug candidates. In this review, we summarize the newest data, considering multiple connections between IL-22 and AD. The presence of circulating IL-22 has been found to correlate with the severity of AD and is identified as a critical factor driving the inflammatory response associated with the condition. Elevated levels of IL-22 in patients with AD are correlated with increased proliferation of keratinocytes, alterations in the skin microbiota, and impaired epidermal barrier function. Collectively, these factors contribute to the manifestation of the characteristic symptoms observed in AD. Full article
(This article belongs to the Special Issue Research on T Cells in Skin Inflammatory Disorders)
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