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Cells
Special Issues
Formation, Aggregation, Persistence, and Maturation of NETs
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Formation, Aggregation, Persistence, and Maturation of NETs

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1513

Special Issue Editors

Prof. Dr. Martin Herrmann

E-Mail Website
Guest Editor
1. Department of Pediatric Surgery, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
2. Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
3. Deutsches Zentrum für Immuntherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
Interests: NET formation; NET maturation; inflammation; immunothrombosis
Special Issues, Collections and Topics in MDPI journals
Dr. Jasmin Knopf

E-Mail Website
Guest Editor
Department of Pediatric Surgery, University Medical Center Mannheim, University Heidelberg, 68167 Mannheim, Germany
Interests: neutrophils; neutrophil extracellular traps; pediatric diseases; pediatric cancers
Special Issues, Collections and Topics in MDPI journals
Dr. Luis E. Munoz

E-Mail Website
Guest Editor
1. Department for Internal Medicine 3, University Hospital Erlangen, Institute for Clinical Immunology, Ulmenweg 18, 91054 Erlangrn, Germany
2. Deutsches Zentrum für Immuntherapie, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangrn, Germany
Interests: innate immunity; inflammation; autoimmunity; anti-tumor immunity; neutrophils
Special Issues, Collections and Topics in MDPI journals
Dr. Maximilian Dölling

E-Mail Website
Guest Editor
Department of General-, Visceral-, Vascular- and Transplant Surgery, University Hospital Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Interests: neutrophils; neutrophil extracellular traps in general, visceral and transplant surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neutrophils are the most abundant leukocytes in human blood and the first line of defense against invading pathogens. They are the first cells recruited to the site of injury and are capable of fighting pathogens via phagocytosis, degranulation, production of reactive oxygen species (ROS) and formation of neutrophil extracellular traps (NETs). The latter are composed of chromatin decorated with neutrophil granular proteins such as myeloperoxidase (MPO) or neutrophil elastase (NE). NETs were first reported in 2004 as a mechanism for neutrophils to trap and kill bacteria. Since then, many other features of NETs have been described. It is now clear that a delicate balance of NET formation and degradation is needed to grant the beneficial effects of NETs and prevent the contribution to pathological states such as autoimmune diseases, lithiasis, aberrant anti-cancer responses or immunothrombosis. This Special Issue of Cells invites all authors to contribute with original research, review or communications exploring the formation, aggregation, persistence and maturation of NETs in tissues during health and disease.

Prof. Dr. Martin Herrmann
Dr. Jasmin Knopf
Dr. Luis E. Munoz
Dr. Maximilian Dölling
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanisms of NET formation
  • NETs in diseases
  • degradation of NETs
  • NET therapeuticals
  • benefical NETs

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Published Papers (1 paper)

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Review

23 pages, 799 KiB  
Review
Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation
by Yuqing Lu, Julia Elrod, Martin Herrmann, Jasmin Knopf and Michael Boettcher
Cells 2024, 13(11), 991; https://doi.org/10.3390/cells13110991 - 6 Jun 2024
Viewed by 1159
Abstract
Post-surgical abdominal adhesions, although poorly understood, are highly prevalent. The molecular processes underlying their formation remain elusive. This review aims to assess the relationship between neutrophil extracellular traps (NETs) and the generation of postoperative peritoneal adhesions and to discuss methods for mitigating peritoneal [...] Read more.
Post-surgical abdominal adhesions, although poorly understood, are highly prevalent. The molecular processes underlying their formation remain elusive. This review aims to assess the relationship between neutrophil extracellular traps (NETs) and the generation of postoperative peritoneal adhesions and to discuss methods for mitigating peritoneal adhesions. A keyword or medical subject heading (MeSH) search for all original articles and reviews was performed in PubMed and Google Scholar. It included studies assessing peritoneal adhesion reformation after abdominal surgery from 2003 to 2023. After assessing for eligibility, the selected articles were evaluated using the Critical Appraisal Skills Programme checklist for qualitative research. The search yielded 127 full-text articles for assessment of eligibility, of which 7 studies met our criteria and were subjected to a detailed quality review using the Critical Appraisal Skills Programme (CASP) checklist. The selected studies offer a comprehensive analysis of adhesion pathogenesis with a special focus on the role of neutrophil extracellular traps (NETs) in the development of peritoneal adhesions. Current interventional strategies are examined, including the use of mechanical barriers, advances in regenerative medicine, and targeted molecular therapies. In particular, this review emphasizes the potential of NET-targeted interventions as promising strategies to mitigate postoperative adhesion development. Evidence suggests that in addition to their role in innate defense against infections and autoimmune diseases, NETs also play a crucial role in the formation of peritoneal adhesions after surgery. Therefore, therapeutic strategies that target NETs are emerging as significant considerations for researchers. Continued research is vital to fully elucidate the relationship between NETs and post-surgical adhesion formation to develop effective treatments. Full article
(This article belongs to the Special Issue Formation, Aggregation, Persistence, and Maturation of NETs)
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