Molecular Therapeutic Advances for Neurodegenerative Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 25 May 2025 | Viewed by 204

Special Issue Editor


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Guest Editor
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L'Aquila, Italy
Interests: neurodegenerative diseases; neurodegeneration; neurological disorders; Parkinson’s disease; probiotics; neuropathic pain; stem cells
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Special Issue Information

Dear Colleagues,

The Special Issue, titled “Molecular Therapeutic Advances for Neurodegenerative Diseases”, focuses on the latest research and developments in understanding and treating neurodegenerative diseases at the molecular level. It aims to highlight innovative therapeutic strategies, including the identification of new molecular targets and the development of novel treatments to combat diseases, such as Alzheimer’s, Parkinson’s, stroke and other neurological disorders.

We are looking for a variety of manuscript types, including the following:

Original Research Articles: Detailed studies presenting new data on molecular mechanisms and therapeutic approaches for neurodegenerative diseases.

Review Articles: Comprehensive overviews of current knowledge and recent advancements in the field.

Communications: Brief reports on novel findings or preliminary data that can stimulate further research. 

Dr. Vanessa Castelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • neurodegeneration
  • neurological disorders

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Published Papers (1 paper)

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Review

19 pages, 744 KiB  
Review
Neuronal Cell Rearrangement During Aging: Antioxidant Compounds as a Potential Therapeutic Approach
by Erjola Bej, Patrizia Cesare, Michele d’Angelo, Anna Rita Volpe and Vanessa Castelli
Cells 2024, 13(23), 1945; https://doi.org/10.3390/cells13231945 (registering DOI) - 23 Nov 2024
Viewed by 5
Abstract
Aging is a natural process that leads to time-related changes and a decrease in cognitive abilities, executive functions, and attention. In neuronal aging, brain cells struggle to respond to oxidative stress. The structure, function, and survival of neurons can be mediated by different [...] Read more.
Aging is a natural process that leads to time-related changes and a decrease in cognitive abilities, executive functions, and attention. In neuronal aging, brain cells struggle to respond to oxidative stress. The structure, function, and survival of neurons can be mediated by different pathways that are sensitive to oxidative stress and age-related low-energy states. Mitochondrial impairment is one of the most noticeable signs of brain aging. Damaged mitochondria are thought to be one of the main causes that feed the inflammation related to aging. Also, protein turnover is involved in age-related impairments. The brain, due to its high oxygen usage, is particularly susceptible to oxidative damage. This review explores the mechanisms underlying neuronal cell rearrangement during aging, focusing on morphological changes that contribute to cognitive decline and increased susceptibility to neurodegenerative diseases. Potential therapeutic approaches are discussed, including the use of antioxidants (e.g., Vitamin C, Vitamin E, glutathione, carotenoids, quercetin, resveratrol, and curcumin) to mitigate oxidative damage, enhance mitochondrial function, and maintain protein homeostasis. This comprehensive overview aims to provide insights into the cellular and molecular processes of neuronal aging and highlight promising therapeutic avenues to counteract age-related neuronal deterioration. Full article
(This article belongs to the Special Issue Molecular Therapeutic Advances for Neurodegenerative Diseases)
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