Immuno-Pathology in Organ and Cell Transplantation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 18073
Special Issue Editors
Interests: molecular pathology; non-coding RNAs; transcriptomic; cell signaling
Special Issues, Collections and Topics in MDPI journals
Interests: innate and acquired immune responses; antiviral immune responses; immune correlates of protection; immunomodulators; vaccines; transplantation rejection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent years have witnessed vast improvements in our understanding of the functioning and the therapeutic modulation of the immune system. Organ and cellular transplantation to cure end-stage chronic diseases has also undergone a number of positive changes, resulting in improved graft function and survival in transplant patients. Thus, the last 10 years have seen increased survival of patients who undergo allograft transplantation. This is mainly due to the availability of improved immunosuppression regimens, full HLA sequencing and matching strategies, improvements in early graft dysfunction detection, and better understanding of the immune mechanisms underlying graft rejection. At the same time, the identification of biomarkers as non-invasive indicators of the pathologic processes leading to rejection would allow for more precise and timely monitoring of early, acute, or chronic graft dysfunction.
Similarly, the world of cell transplantation has exploded both in terms of cell types available for transplantation and medical applications. In this scenario, adoptive cell therapy (also known as cellular immunotherapies) has offered curative opportunities for cancer patients for whom chemotherapy has failed. Finally, advances in genetic engineering and stem cell technology have contributed to rapid developments of functional organs from induced pluripotent stem (IPS) cells.
All these advances notwithstanding, immune-mediated pathological mechanisms of graft rejection, graft-versus-host disease, infections, and, finally, increased susceptibility to the development of tumors hinder the long-term survival of transplant recipients and of patients undergoing cellular immunotherapies. Many questions still require answers in order to maximize successful graft outcomes and use of these therapies.
This Special Issue offers an open access forum that aims to bring together translational research and medical advances (both in the form of reviews and original research) to improve our understanding of the immunopathogenesis of organ or cellular transplant. Suggested potential topics may include immune-based or genomic biomarkers, molecular or proteomic signatures, signaling pathways involved in transplant outcome, and novel therapeutic approaches.
Dr. Valentina Vaira
Prof. Dr. Daria Lucia Trabattoni
Guest Editors
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