Molecular and Cellular Mechanisms Underlying Meiotic Divisions
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Reproductive Cells and Development".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 2863
Special Issue Editors
Interests: oocyte meiotic divisions in Xenopus; signal transduction; kinases and phosphatases; biochemistry of cell division; oogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
At the end of the 19th century, meiosis was first observed by Oscar Hertwig in sea urchins and Edouard Van Beneden in roundworms, and its significance in terms of reproduction and heredity was understood by August Weismann. Since then, many scientists worldwide have focused on deciphering the mechanisms underlying these two very particular cell divisions, which have played an important part in creating the diversity of life on the planet. Meiosis is a key process in sexual reproduction. The two meiotic divisions, which proceed without any intervening phase of DNA duplication, generate cells containing a haploid genome: the gametes of multicellular beings and the sex cells of unicellular eukaryotes. Subsequent fusion between haploid cells, via fertilization in multicellular organisms or mating in single-cell organisms, re-establishes diploidy and produces a cell whose genome is entirely different from those of the parental cells.
Nearly 150 years after the pioneering observations of Hertwig and Van Beneden, many questions remain open. Nevertheless, the past decade has seen great advances in understanding the many specialized and regulatory processes underlying meiotic divisions: communication and interactions between germ cells and somatic cells, induction of meiotic divisions by external factors, complex signaling cascades, finely-tuned expression of maternal information, highly specialized cell divisions, specific chromosome segregation supported by adapted cytoskeleton organization and chromatin remodeling, major restructuring of the intracellular organization, detection and repair of possible defects of these divisions, acquisition of fertilizability, and many others.
This Special Issue of Cells will present a comprehensive overview of the basic mechanisms orchestrating meiotic divisions, including chapters on diverse model organisms that offer an evolutionary perspective to meiosis. Based on the contributions of world-leading experts, this Special Issue will be an essential reference for students, researchers, and physicians in the exciting field of research on this fascinating cell process.
Dr. Catherine Jessus
Dr. Enrico Maria Daldello
Guest Editors
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Keywords
- meiotic division
- meiotic spindle
- meiotic maturation
- oocyte
- oogenesis
- spermatozoid
- spermatogenesis
- gamete
- egg
- fertilization
- mating
- oocyte to embryo transition
- haploidy
- aneuploidy
- cell division control
- cell division checkpoints
- chromatin remodeling
- regulation of protein translation
- regulation of maternal mRNAs
- model organisms
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