State of the Art and Future Prospects in Stem Cell Transplantation

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 3681

Special Issue Editor


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Guest Editor
Bone Marrow Transplant Program, Penn State Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA
Interests: bone marrow transplantation; graft versus host disease; complications after stem cell transplantation; reduced intensity stem cell transplantation; HLA-mismatch stem cell transplantation; graft engineering; cell therapy; and gene therapy
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Special Issue Information

Dear Colleagues,

Hematopoietic Stem Cell Transplantation (HSCT) has emerged as a pivotal tool against hematological malignancies. This Special Issue of "Cells" illuminates state-of-the-art advancements in HSCT, focusing on transformative strides in treating leukemia, lymphoma, and myeloma. Since the inception of allogeneic stem cell transplantation in the mid-20th century, the field has seen remarkable progress. The shift from conventional myeloablative regimens to prevalent reduced-intensity regimens signifies this evolution. The donor landscape has also broadened with cord blood transplantation and the innovative haploidentical HSCT using PTCy. A significant milestone is the recent incorporation of the Minimal Residual Disease (MRD) strategy, making HSCT decisions more scientific and precise. While we celebrate these advancements, challenges like post-transplant relapse, GVHD, and optimal donor selection remain. This Special Issue provides a comprehensive snapshot of the current landscape, emphasizing groundbreaking research and the evolving paradigms in stem cell transplantation for hematological malignancies. As readers explore these articles, from seasoned experts to newcomers, they are invited to discover the innovations shaping the future of hematologic oncology.

Prof. Dr. Shin Mineishi
Guest Editor

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Keywords

  • hematopoietic stem cell transplantation
  • conditioning
  • graft-versus-host disease
  • minimal residual disease
  • HSCT

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Published Papers (2 papers)

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16 pages, 1246 KiB  
Review
High-Dose Chemotherapy and Autologous or Allogeneic Transplantation in Aggressive B-Cell Lymphoma—Is There Still a Role?
by Michael Daunov and Koen van Besien
Cells 2024, 13(21), 1780; https://doi.org/10.3390/cells13211780 - 27 Oct 2024
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Abstract
Novel therapies such as CAR-T, BTK inhibitors and PD-1 inhibitors have changed the management of aggressive B-cell lymphomas. Nonetheless, these novel therapies have their own risk of late toxicities including second malignancies. They also create a subgroup of patients with relapse, treatment failure, [...] Read more.
Novel therapies such as CAR-T, BTK inhibitors and PD-1 inhibitors have changed the management of aggressive B-cell lymphomas. Nonetheless, these novel therapies have their own risk of late toxicities including second malignancies. They also create a subgroup of patients with relapse, treatment failure, or indefinite maintenance. We discuss the current role of autologous and allogeneic stem cell transplantation in this context. In patients with recurrent diffuse large B-cell lymphoma, CAR-T cell treatment has largely replaced autologous transplant. Autologous transplant should be considered in patients with late relapses and in selected patients with T-cell-rich B-cell lymphoma, where CAR-T cell therapy may be less effective. It also remains the treatment of choice for consolidation of patients with primary CNS lymphoma. In mantle cell lymphoma, intensive chemotherapy combined with BTK inhibitors and rituximab results in excellent outcomes, and the role of autologous transplantation is declining. In Hodgkin’s lymphoma, autologous transplant consolidation remains the standard of care for patients who failed initial chemotherapy. Allogeneic transplantation has lower relapse rates but more complications and higher non-relapse mortality than autologous transplantation. It is usually reserved for patients who fail autologous transplantation or in whom autologous stem cells cannot be collected. It may also have an important role in patients who fail CAR-T therapies. The increasing complexity of care and evolving sequencing of therapies for patients with aggressive B-cell lymphomas only emphasizes the importance of appropriate patient selection and optimal timing of stem cell transplantation. Full article
(This article belongs to the Special Issue State of the Art and Future Prospects in Stem Cell Transplantation)
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8 pages, 551 KiB  
Commentary
The Evolution of Hematopoietic Stem Cell Transplantation to Overcome Access Disparities: The Role of NMDP
by Steven M. Devine
Cells 2024, 13(11), 933; https://doi.org/10.3390/cells13110933 - 29 May 2024
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Abstract
NMDP recognizes that despite advances in hematopoietic stem cell transplantation (HSCT) and other cell therapies, not all patients have equitable access to treatment, and disparities in outcomes remain. This paper explores the recent work of NMDP to accelerate progress and expand access to [...] Read more.
NMDP recognizes that despite advances in hematopoietic stem cell transplantation (HSCT) and other cell therapies, not all patients have equitable access to treatment, and disparities in outcomes remain. This paper explores the recent work of NMDP to accelerate progress and expand access to more patients through transformative clinical research, particularly in the use of mismatched unrelated donors for HSCT. Full article
(This article belongs to the Special Issue State of the Art and Future Prospects in Stem Cell Transplantation)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Significance of Measurable Residual Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia
Authors: Margery Gang, Megan Othus, Roland B. Walter
Affiliation: Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA

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