The Cell Biology of Inositol
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 February 2025 | Viewed by 146
Special Issue Editors
Interests: inositol in endocrine control and carcinogenesis; tumor reversion through epigenetic and microenvironment modification; biophysical control of morphogenesis and differentiation
Special Issues, Collections and Topics in MDPI journals
2. EGOI (The Experts Group on Inositol in Basic and Clinical Research and PCOS), Rome, Italy
Interests: inositol in endocrine control and polycystic ovary syndrome; inositol in gynecological diseases; inositol and steroid control in ovary and oocyte development
Special Issue Information
Dear Colleagues,
Inositol (myo-inositol) plays a critical role in several physiological pathways, and increasing evidence points out that it is involved in several pathological conditions, alongside with its main isomers (scyllo- and D-chiro-inositol). Myo-inositol is at the root of many secondary derivatives— inositol phosphates, phosphoinositides, and pyrophosphates—produced through a branched metabolism that spreads across many pathways. Despite the impressive body of studies released in the past thirty years, we are still missing the full appraisal regarding some critical aspects of inositol physiology. What is the fate of myo-inositol picked up by cells? How is the endogenous myo-inositol synthesis during specific conditions regulated (inositol starvation, inositol addition, cancer growth, morphogenesis, etc.)? Does endogenous inositol take a different intracellular pathway with respect to the exogenous poliol? Does inositol undergo a different metabolism in cancerous cells? Could inositol interfere with endocrine control either by itself or through secondary derivatives? Moreover, since its inclusion within the membranes of eukaryotic cells, inositol and its derivatives seem to play a unique role in mediating the crosstalk among the cells and their microenvironment, representing an important constituent of the bio-dynamical interface. Therefore, it is not surprising that de-regulation of inositol metabolism could viewed as a significant player during several illnesses, including cancer, endocrine disorders, neurological disorders, and metabolic diseases.
Relevant topics:
- Assessment of the nutritional status of inositol: dietary requirements in health, development, and disease;
- Analytical strategies in assessing inositol (and metabolites) status in organic fluids and tissues;
- Inositol(s) and phosphate derivatives in cell membranes and organelles;
- Intracellular metabolism of myo-inositol;
- Myo-inositol and cell metabolism: focus on insulin signaling;
- Inositol(s) in endocrine control of steroidogenesis;
- Inositol(s) and neurodegenerative diseases;
- Inositol(s) and cancer.
Dr. Mariano Bizzarri
Dr. Simona Dinicola
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inositol
- organic fluids and tissues
- cell membranes and organelles
- cell metabolism
- nutrition
- neurodegenerative diseases
- cancer
- inositol pyrophosphates
- inositol phosphates and phosphoinositides
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
