Immune-Related Adverse Events in Cancer Patients—From Pathophysiology to Treatment and Associations with Outcomes
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (1 November 2023) | Viewed by 583
Special Issue Editors
2. Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
Interests: colorectal cancer; urological malignancies; lung cancer; targeted therapy; immunotherapy; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunotherapy represents one of the most effective systemic anticancer therapies; it has been substantially developed in recent years, leading to great progress in the treatment of a wide spectrum of malignancies. Immunotherapy is usually accompanied by specific immune-related side events (irAEs) caused by impairment of immunotolerance to nontumoral tissues. The aims of understanding the pathophysiologic mechanisms underlying irAEs, finding predictive biomarkers, and developing optimal treatment strategies are of great importance in current experimental and clinical research. Moreover, there is an increasing body of evidence that the development of irAEs is associated with effects of immunotherapy; however, this association remains poorly understood. Additionally, there is an increasing number of agents influencing the immune system, used across various medical disciplines in different indications, with largely unknown impacts on cancer immunotherapies and their irAEs.
This Special Issue of Cells will present research articles and reviews that cover the scope of irAEs from the point of view of both experimental and clinical researchers. The articles should focus on various aspects of irAEs, including their pathophysiology, predictive biomarkers, treatment strategies, and associations with outcomes for patients. All scientists working in these fields are cordially invited to submit their manuscripts. We are looking forward to your contributions to this Special Issue.
Dr. Ondřej Fiala
Dr. Václav Vaněček
Guest Editors
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Keywords
- immunotherapy
- adverse effects
- irAE
- pathophysiology
- prediction
- outcome
- efficacy
- outcome
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