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Children
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New Advances in Pediatric Liver Transplantation
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New Advances in Pediatric Liver Transplantation

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: closed (10 October 2024) | Viewed by 859

Special Issue Editors

Dr. Sylwia Szymanska

E-Mail Website
Guest Editor
Department of Pathology, The Children's Memorial Health Institute, 04-736 Warsaw, Poland
Interests: transplantation; paediatric pathology; liver diseases; nephropathology; inflammatory bowel disease
Dr. Małgorzata Markiewicz-Kijewska

E-Mail Website
Guest Editor
Department of Pediatric Surgery and Organ's Transplantation, The Children's Memorial Health Institute, 04-736 Warsaw, Poland
Interests: transplantation; paediatric pathology; liver diseases; nephropathology; inflammatory bowel disease

Special Issue Information

Dear Colleagues,

Liver transplantation (LT) is the established management of end-stage liver disease in children with good long-term graft and patient survival. Unfortunately, instances of liver graft loss are still common despite immunosuppressive regimens including newer antibodies, fusion proteins and low molecular weight drugs. Core needle biopsy of the liver remains the gold standard to diagnose abnormalities of the transplanted liver. Therefore, it is highly important to develop novel biomarkers and techniques that allow for quick and effective recognition of changes occurring in the liver allograft.

Dr. Sylwia Szymanska
Dr. Małgorzata Markiewicz-Kijewska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibody-mediated rejection and cellular rejection
  • liver biopsy
  • immunohistochemical markers
  • solid organ transplantation in children
  • immunological processes

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Published Papers (1 paper)

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Research

11 pages, 2283 KiB  
Article
Prediction of Whole Liver Graft Weight Based on Biometric Variables in Paediatric and Adult Liver Donors
by Maria Kuksin, Valeska Bidault Jourdainne, Guillaume Rossignol, Philippe Aegerter, Géraldine Hery, Jean-Paul Teglas, Virginie Fouquet, Sophie Branchereau and Florent Guérin
Children 2024, 11(10), 1248; https://doi.org/10.3390/children11101248 - 16 Oct 2024
Viewed by 556
Abstract
Background/Objectives: In paediatric liver transplantation, donor–recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor’s biometric parameters. Methods: We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected [...] Read more.
Background/Objectives: In paediatric liver transplantation, donor–recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor’s biometric parameters. Methods: We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight. Results: In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R2 = 0.86 and p-value < 10−5. We also determined two models in adult donors using donor weight and height (R2 = 0.33, p < 10−4) and donor weight and sternal height (R2 = 0.38, p < 10−4). The models proved valid based on our external dataset of 245 patients from two institutions. Conclusions: In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation. Full article
(This article belongs to the Special Issue New Advances in Pediatric Liver Transplantation)
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