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Coatings
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Antiviral Coating as Sustainable Measure to Fight Viral Pandemic
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Antiviral Coating as Sustainable Measure to Fight Viral Pandemic

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 22703

Special Issue Editor

Dr. Ajay Vikram Singh

E-Mail Website
Guest Editor
Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany
Interests: materials engineering and antibacterial surfaces; toxicology; micropatterning; micro/nanorobotics; magnetic applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considering the global pandemic and Covid-19's potential threat, researchers, virologists, and material scientists are rushing to understand the surface stability of the novel virus, which could thereby lead to the creation of antiviral coatings that could substantially reduce the virus' stabilization on different surfaces of high-traffic objects such as elderly homes, hospitals, and doors and windows of public transport. Thereby, it could significantly reduce community transmission and emergence of the new positive cases currently being witnessed in the global Coronavirus SARS-Cov-2 (Covid-19) infection worldwide. An important topic to focus on, surface coatings will be an important means of developing anti-infective solutions in the post-corona era to diminish transmission of viral infections. To support current research and development in this field, Coatings will contribute to fighting this viral pandemic by releasing this Special Issue entitled "Antiviral coating as sustainable measure to fight viral pandemic" to provide an overview of published scientific knowledge with a focus on coating approaches.  

This Special Issue aims to present brief correspondence, research papers, and review articles addressing problems and recent developments in surface modification techniques that function as antiviral coatings. Specifically, topics of interest will include, but are not limited to, materials coatings as aligned with the journal's wider scope in the sense of epidemiological research on antiviral surface modification as global solutions. We are also open to considering subjects and submissions on socio-medical aspects of antiviral coatings for prosthetic rehabilitation.

Dr. Ajay Vikram Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Research

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18 pages, 2905 KiB  
Article
Validating Anti-Infective Activity of Pleurotus Opuntiae via Standardization of Its Bioactive Mycoconstituents through Multimodal Biochemical Approach
by Aprajita Tiwari Pandey, Ishan Pandey, Anurag Kanase, Amita Verma, Beatriz Garcia-Canibano, Sarada Prasad Dakua, Shidin Balakrishnan and Mohan Prasad Singh
Coatings 2021, 11(4), 484; https://doi.org/10.3390/coatings11040484 - 20 Apr 2021
Cited by 7 | Viewed by 3672
Abstract
Mushrooms produce a variety of bioactive compounds that are known to have anti-pathogenic properties with safer and effective therapeutic effects in human disease prognosis. The antibacterial activity of ethanol and methanol extracts of Pleurotus opuntiae were checked against pathogenic microorganisms viz. Pseudomonas aeruginosa [...] Read more.
Mushrooms produce a variety of bioactive compounds that are known to have anti-pathogenic properties with safer and effective therapeutic effects in human disease prognosis. The antibacterial activity of ethanol and methanol extracts of Pleurotus opuntiae were checked against pathogenic microorganisms viz. Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis NCIM 2300, Proteus vulgaris NCIM 5266, Serratia marcescens NCIM 2078, Shigella flexeneri NCIM 5265, Moraxella sp. NCIM 2795, Staphylococcus aureus ATCC 25923 by agar well diffusion method at different concentrations of the extracts. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts was determined by INT (Iodonitrotetrazolium chloride) colorimetric assay. Extracts were standardized by thin layer chromatography (TLC) in different solvent systems. The Retention factors (Rf) of different compounds were calculated by high performance TLC (HPTLC) fingerprinting at UV 254, 366, and 540 nm before and after derivatization. The ethanol and methanol extracts of P. opuntiae showed bactericidal activity against all the test pathogens at MIC values of 15.6 to 52.08 mg/mL and 20.81 to 52.08 mg/mL respectively. Whereas the MBC values for ethanol and methanol extract of P. opuntiae against all pathogens were recorded as 26.03 to 62.5 mg/mL and 125 mg/mL respectively. Preliminary mycochemical screening of both the extracts revealed high contents of bioactive compounds. Amongst all the solvent systems used in TLC, the best result was given by chloroform + hexane (8:2) which eluted out 5 different compounds (spots). HPTLC results revealed spots with different Rf values for all the 24 compounds present. Thus, it can be inferred from the present investigation that the mycoconstituents could be an alternative medication regimen and could play a role in new drug discoveries against different infections. Further, the antimicrobial components of these mushrooms can be transformed to bioengineered antimicrobial coatings for surfaces, drug and other hybrid systems for public health implications in combating persistent infections. Full article
(This article belongs to the Special Issue Antiviral Coating as Sustainable Measure to Fight Viral Pandemic)
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Review

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26 pages, 3672 KiB  
Review
In Silico Modeling as a Perspective in Developing Potential Vaccine Candidates and Therapeutics for COVID-19
by Reham F. Barghash, Iten M. Fawzy, Vaisali Chandrasekar, Ajay Vikram Singh, Uma Katha and Asmaa A. Mandour
Coatings 2021, 11(11), 1273; https://doi.org/10.3390/coatings11111273 - 20 Oct 2021
Cited by 23 | Viewed by 4381
Abstract
The potential of computational models to identify new therapeutics and repurpose existing drugs has gained significance in recent times. The current ‘COVID-19’ pandemic caused by the new SARS CoV2 virus has affected over 200 million people and caused over 4 million deaths. The [...] Read more.
The potential of computational models to identify new therapeutics and repurpose existing drugs has gained significance in recent times. The current ‘COVID-19’ pandemic caused by the new SARS CoV2 virus has affected over 200 million people and caused over 4 million deaths. The enormity and the consequences of this viral infection have fueled the research community to identify drugs or vaccines through a relatively expeditious process. The availability of high-throughput datasets has cultivated new strategies for drug development and can provide the foundation towards effective therapy options. Molecular modeling methods using structure-based or computer-aided virtual screening can potentially be employed as research guides to identify novel antiviral agents. This review focuses on in-silico modeling of the potential therapeutic candidates against SARS CoVs, in addition to strategies for vaccine design. Here, we particularly focus on the recently published SARS CoV main protease (Mpro) active site, the RNA-dependent RNA polymerase (RdRp) of SARS CoV2, and the spike S-protein as potential targets for vaccine development. This review can offer future perspectives for further research and the development of COVID-19 therapies via the design of new drug candidates and multi-epitopic vaccines and through the repurposing of either approved drugs or drugs under clinical trial. Full article
(This article belongs to the Special Issue Antiviral Coating as Sustainable Measure to Fight Viral Pandemic)
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30 pages, 3073 KiB  
Review
Naphthoquinones and Their Derivatives: Emerging Trends in Combating Microbial Pathogens
by Nishigandha S. Mone, Srushti A. Bhagwat, Deepansh Sharma, Manohar Chaskar, Rajendra H. Patil, Paolo Zamboni, Neelu N. Nawani and Surekha K. Satpute
Coatings 2021, 11(4), 434; https://doi.org/10.3390/coatings11040434 - 9 Apr 2021
Cited by 38 | Viewed by 8055
Abstract
In the current era, an ever-emerging threat of multidrug-resistant (MDR) pathogens pose serious health challenges to mankind. Researchers are uninterruptedly putting their efforts to design and develop alternative, innovative strategies to tackle the antibiotic resistance displayed by varied pathogens. Among several naturally derived [...] Read more.
In the current era, an ever-emerging threat of multidrug-resistant (MDR) pathogens pose serious health challenges to mankind. Researchers are uninterruptedly putting their efforts to design and develop alternative, innovative strategies to tackle the antibiotic resistance displayed by varied pathogens. Among several naturally derived and chemically synthesized compounds, quinones have achieved a distinct position to defeat microbial pathogens. This review unleashes the structural diversity and promising biological activities of naphthoquinones (NQs) and their derivatives documented in the past two decades. Further, realizing their functional potentialities, researchers were encouraged to approach NQs as lead molecules. We have retrieved information that is dedicated on biological applications (antibacterial, antifungal, antiparasitic) of NQs. The multiple roles of NQs offer them a promising armory to combat microbial pathogens including MDR and the ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) group. In bacteria, NQs may exhibit their function in the following ways (1) plasmid curing, (2) inhibiting efflux pumps (EPs), (3) generating reactive oxygen species (ROS), (4) the inhibition of topoisomerase activity. Sparse but meticulous literature suggests the mechanistic roles of NQs. We have highlighted the possible mechanisms of NQs and how the targeted drug synthesis can be achieved via molecular docking analysis. This bioinformatics-oriented approach will explicitly lead to the development of effective and most potent drugs against targeted pathogens. The mechanistic approaches of emerging molecules like NQs might prove a milestone to defeat the battle against microbial pathogens. Full article
(This article belongs to the Special Issue Antiviral Coating as Sustainable Measure to Fight Viral Pandemic)
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Other

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7 pages, 847 KiB  
Brief Report
Survival of SARS-CoV-2 on Non-Porous Materials in an Experimental Setting Representative of Fomites
by Laura Bonil, Guillaume Lingas, Damien Coupeau, Jean-Christophe Lucet, Jérémie Guedj, Benoît Visseaux and Benoît Muylkens
Coatings 2021, 11(4), 371; https://doi.org/10.3390/coatings11040371 - 24 Mar 2021
Cited by 7 | Viewed by 4294
Abstract
To better understand plausible SARS-CoV-2 transmission through fomites, a physiological model was designed to analyze the decay rate of SARS-CoV-2 infectivity. We focused on non-porous materials present in high-touch surfaces or used as containment barrier surfaces, namely glass, acrylic glass, photo-activated coated glass, [...] Read more.
To better understand plausible SARS-CoV-2 transmission through fomites, a physiological model was designed to analyze the decay rate of SARS-CoV-2 infectivity. We focused on non-porous materials present in high-touch surfaces or used as containment barrier surfaces, namely glass, acrylic glass, photo-activated coated glass, stainless steel and aluminium. SARS-CoV-2 survival depended on the material considered, with half-lives on glass, photo-activated coated glass, stainless steel and aluminium equal to 6.9, 4.1, 3.5 and 2.3 h, respectively. This study highlights the potential utility of coatings in the fight against the current threat. In addition, it spotlights the need for standardizing assays to assess indirect transmission of COVID-19. Full article
(This article belongs to the Special Issue Antiviral Coating as Sustainable Measure to Fight Viral Pandemic)
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