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Crystals
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Biomaterials for Medical and Dental Applications
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Biomaterials for Medical and Dental Applications

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Inorganic Crystalline Materials".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4099

Special Issue Editors

Dr. Żaneta Anna Mierzejewska

E-Mail Website
Guest Editor
Faculty of Mechanical Engineering, Institute of Biomedical Engineering, Bialystok University of Technology, Wiejska 45 C, 15-351 Bialystok, Poland
Interests: additive manufacturing, materials characterization, biomedical alloys, biomaterials
Dr. Alokesh Pramanik

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Curtin University, GPO Box U1987, Perth, WA 6845, Australia
Interests: machining processes; CAD/CAM; digital manufacturing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials are a unique group of materials whose special features are biocompatibility and bifunctionality, which determine the proper adaptation of the material in the tissue environment.The presence of the biomaterial in the body should not cause allergic, mutagenic, carcinogenic, or immunological reactions.  Therefore, the biomaterial should be characterized by high biotolerance, corrosion resistance, and strength properties adapted to the replaced tissues.These requirements for biomaterials are very diverse, which is the result of the multitude of their potential applications and the growing expectations. Biomaterials engineering is therefore an intensively developing area of science in the field of materials engineering.This is caused by the growing demand for new materials, the design of which should combine elements of material engineering, medicine, immunology, and microbiology.

This Special Issue on “Biomaterials for Medical and Dental Applications” aims to publish research and review articles on biomaterials’ applications and will cover several topics, including but not limited to: 

  • New technology and biomaterials for regenerative medicine;
  • Novel biomaterials for orthopedic/musculoskeletal tissue engineering;
  • Novel biomaterials for regenerative medicine;
  • Surface functionalization or biomaterial modification;
  • In vitro and in vivo study of osseointegration;
  • Metallic biomaterials for medical applications;
  • Development of new metallic alloys for biomedical applications;
  • Biodegradable biomaterials and metallic implants in the tissue environment;
  • Material–tissue interfaces: the role of surface;
  • Toxicology and biocompatibility of biomaterials.

We invite all colleagues to submit manuscripts (full papers, reviews, or notes) in open access to this Special Issue. We encourage you to disseminate this invitation to any colleagues who may be interested.

Dr. Żaneta Anna Mierzejewska
Dr. Alokesh Pramanik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials manufacturing
  • microstructural characterization/properties
  • biocompatibility
  • biofunctionalization
  • biomaterials degradation
  • reliability of biomaterials
  • trends in medical materials

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

15 pages, 7677 KiB  
Article
Identification of Proteins Adsorbed on Hydroxyapatite Ceramics with a Preferred Orientation to a-Plane
by Erika Onuma, Takayuki Honda, Hideyuki Yoshimura, Tappei Nishihara, Atsushi Ogura, Nobuyuki Kanzawa and Mamoru Aizawa
Crystals 2023, 13(9), 1318; https://doi.org/10.3390/cryst13091318 - 29 Aug 2023
Cited by 3 | Viewed by 1523
Abstract
Protein adsorption is essential for determining material biocompatibility and promoting adherent cell growth. In this study, we focused on the a-plane structure of hydroxyapatite (HAp). This a-plane structure closely resembles the crystal plane where apatite is exposed in long bones. We [...] Read more.
Protein adsorption is essential for determining material biocompatibility and promoting adherent cell growth. In this study, we focused on the a-plane structure of hydroxyapatite (HAp). This a-plane structure closely resembles the crystal plane where apatite is exposed in long bones. We conducted protein adsorption experiments using HAp ceramics with a preferred orientation to a-planes (aHAp), employing bovine serum albumin (BSA), lysozyme, and fetal bovine serum (FBS) as protein models to mimic the in vivo environment. Higher zeta potential and contact angle values were found in aHAp than in HAp ceramics fabricated from commercial HAp powder (iHAp). Bradford-quantified protein adsorption revealed BSA adsorption of 212 ng·mm−2 in aHAp and 28.4 ng mm−2 in iHAp. Furthermore, the Bradford-quantified protein adsorption values for FBS were 2.07 μg mm−2 in aHAp and 1.28 µg mm−2 in iHAp. Two-dimensional electrophoresis (2D-PAGE) showed a higher number of protein-derived major spots in aHAp (37 spots) than in iHAp (12 spots). Mass spectrometry analysis of the resulting 2D-PAGE gels revealed proteins adsorbed on aHAp, including secreted frizzled-related protein 3 and vitamin K epoxide reductase complex 1, which are involved in cellular bone differentiation. Overall, these proteins are expected to promote bone differentiation, representing a characteristic property of aHAp. Full article
(This article belongs to the Special Issue Biomaterials for Medical and Dental Applications)
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12 pages, 4495 KiB  
Article
Intrafibrillar Growth of Hydroxyapatite Nanocrystals in Multiscale Collagen
by Bingyu Xue, Yidi Li, Zhengyi Fu, Hang Ping and Kun Wang
Crystals 2023, 13(4), 692; https://doi.org/10.3390/cryst13040692 - 18 Apr 2023
Cited by 2 | Viewed by 1800
Abstract
Collagen fibrils hierarchically assemble from microscale to macroscale, which endows the natural composite bone with good mechanical properties and remodeling functions. Revealing the intrafibrillar growth process of hydroxyapatite nanocrystals of collagen will guide the research of bone repair or collagen-based composites. Herein, we [...] Read more.
Collagen fibrils hierarchically assemble from microscale to macroscale, which endows the natural composite bone with good mechanical properties and remodeling functions. Revealing the intrafibrillar growth process of hydroxyapatite nanocrystals of collagen will guide the research of bone repair or collagen-based composites. Herein, we investigated the mineralization of multiscale collagen matrices and strongly proved the intrafibrillar hydroxyapatite nanocrystals in the collagen fibrils. The hydroxyapatite nanocrystals were deposited within collagen fibrils with co-orientation along the (002) crystal plane, which is the longitude of the fibril. The whole growth process was captured by TEM to demonstrated the five stages of the intrafibrillar growth process of hydroxyapatite nanocrystals. The infiltration and transformation of amorphous calcium phosphate in isolated collagen fibrils are both demonstrated. The intrafibrillar growth process of hydroxyapatite nanocrystals in collagen film was also investigated, showing that the growth area of collagen films increased linearly with time and the growth process. By studying the in situ mineralization under different reaction conditions, the kinetic equation of the mineralized area of collagen film under each condition was obtained, and the optimal hydroxyapatite mineralized solution was proved to be a solution with polyacrylic acid of 50 μG/mL and a pH of 7.5. Our work provides more detailed information of the growth process of HAP nanocrystals during the mineralization of collagen at different scales and would contribute to future research on the formation process of more minerals in collagen. Full article
(This article belongs to the Special Issue Biomaterials for Medical and Dental Applications)
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