The Realm of Pharmaceutical Multicomponent Forms
A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Biomolecular Crystals".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 3962
Special Issue Editors
Interests: mechanochemistry; deep eutectic solvents; green chemistry; pharmaceutical formulations; crystal engineering; multivariate data analysis
Special Issues, Collections and Topics in MDPI journals
Interests: mechanochemistry; antibiotic coordination frameworks; crystal engineering; supramolecular chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of Crystals highlights the use of co-crystallization and the development of other multicomponent forms in the pharmaceutical context, as a tool to improve drug properties and consequently tackle specific drug problems.
Co-crystallization is a crystal engineering approach in which a drug is combined to one or more coformers by non-covalent interactions with the intention of tuning drugs’ properties, such as solubility, bioavailability, stability, and mechanical properties, among others. The coformers should be molecules considered safe for pharmaceutical applications or even other drugs. Nevertheless, in addition to co-crystals, also other multicomponent forms, such as solvates, ionic co-crystals, molecular salts, eutectic mixtures, and even co-amorphous materials, can be synthesized, leading to significant improvements in drug properties.
During the development process, it is important to bear in mind that industry in general, and the pharmaceutical industry in particular, is changing the way of producing new materials, using more sustainable methods with less toxic materials. Solvent-free synthetic methods are being investigated, and the paradigm of batch manufacturing is changing to continuous manufacturing, decreasing the amount of residues and increasing energetic efficiency.
The aim of this Special Issue is to show how different multicomponent forms can improve drug properties and how they can be transposed to industrial settings. Therefore, works related to the development of all the abovementioned multicomponent forms are welcome in this Special Issue. Additionally, industrial applications of sustainable and greener co-crystallization methods are encouraged.
Dr. Mafalda Cruz Sarraguça
Dr. Vânia André
Guest Editors
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Keywords
- Co-crystallization
- Co-crystals
- Ionic co-crystals
- Molecular salts
- Eutectic mixtures
- Co-amorphous
- Industrial applications
- Sustainability
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