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Diagnostics
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Updates in the Diagnosis and Management of Autoimmune Diseases
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Updates in the Diagnosis and Management of Autoimmune Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: closed (10 September 2024) | Viewed by 1552

Special Issue Editors

Dr. Durga Prasanna Misra

E-Mail Website
Guest Editor
Department of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India
Interests: Takayasu arteritis; ANCA vasculitis; systemic vasculitis; cardiovascular risk in rheumatic diseases; systemic sclerosis; systematic reviews; meta-analyses
Special Issues, Collections and Topics in MDPI journals
Dr. Corrado Campochiaro

E-Mail Website
Guest Editor
IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, 20132 Milan, Italy
Interests: systemic sclerosis; targeted treatments; interstitial lung disease; digital ulcers; calcinosis; pulmonary arterial hypertension; autoantibodies; progression; disease outcomes; Takayasu arteritis; giant cell arteritis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autoimmune diseases are an important cause of morbidity and early mortality in the general population. Autoimmune diseases affect individuals from childhood to older age groups. These diseases may be organ-specific (such as myasthenia gravis or autoimmune thyroiditis) or systemic (such as rheumatoid arthritis, spondyloarthritis, systemic sclerosis, systemic lupus erythematosus, Sjogren’s syndrome, inflammatory myositis, or systemic vasculitis). The diagnosis and management of autoimmune diseases are areas of active evolution. Through clinical studies of large cohorts, various prognostic markers of autoimmune diseases are increasingly being identified. The same also holds true with regard to molecular biomarkers of autoimmune disease diagnosis and prognosis, whether these biomarkers are genomic, proteomic, or metabolomic. The possibility of expanding the knowledge of specific molecular targets has also led to the approval of newer drugs for the management of autoimmune diseases or the inclusion of new clinical indications for already approved targeted therapies. Moreover, preclinical research on autoimmune diseases and the mechanisms of autoimmunity over the past few years has been extremely productive, with many ground-breaking steps. This Special Issue focuses on updates in the diagnosis, pathogenesis, prognosis, and treatment of autoimmune diseases, particularly on systemic autoimmune diseases. Original articles and review articles on these aspects of autoimmune diseases are welcomed. All the articles shall undergo peer review as per the standard protocols of the journal and be accepted only after successful peer review.

Dr. Durga Prasanna Misra
Dr. Corrado Campochiaro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmune diseases
  • rheumatoid arthritis
  • spondyloarthritis
  • systemic sclerosis
  • Sjogren’s syndrome
  • vasculitis
  • inflammatory myositis
  • juvenile idiopathic arthritis
  • systemic lupus erythematosus

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Published Papers (2 papers)

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12 pages, 876 KiB  
Article
Comparative Analysis of Glandular and Extraglandular Manifestations in Primary and Secondary Sjögren’s Syndrome: A Study in Two Academic Centers in North-East Romania
by Alexandru Lodba, Codrina Ancuta, Diana Tatarciuc, Angela Ghiorghe, Luciana-Oana Lodba and Cristina Iordache
Diagnostics 2024, 14(21), 2367; https://doi.org/10.3390/diagnostics14212367 - 23 Oct 2024
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Abstract
Background: This study investigates the clinical characteristics and differences between primary Sjögren’s Syndrome (pSS) and secondary Sjögren’s Syndrome (sSS) in a cohort of 50 patients. Methods: Conducted across two academic facilities in North-East Romania, the study emphasizes the importance of glandular and extraglandular [...] Read more.
Background: This study investigates the clinical characteristics and differences between primary Sjögren’s Syndrome (pSS) and secondary Sjögren’s Syndrome (sSS) in a cohort of 50 patients. Methods: Conducted across two academic facilities in North-East Romania, the study emphasizes the importance of glandular and extraglandular manifestations, focusing on salivary flow rates, pH levels, and buffer capacity. Patients were diagnosed using the 2016 ACR-EULAR classification criteria, with a detailed examination including salivary tests, biopsies, and antibody presence. Results: The findings highlight significant differences between pSS and sSS, particularly in salivary function, with pSS patients exhibiting more severe glandular dysfunction. The study also notes a higher prevalence of inflammatory joint involvement in sSS patients, often associated with rheumatoid arthritis. Statistical analysis revealed correlations between salivary parameters and disease progression, underscoring the necessity of tailored treatment strategies. The research suggests that lower salivary flow rates and altered pH levels in pSS patients contribute to compromised oral health, including increased dental cavities and periodontal disease. Conclusions: The study’s results contribute to a deeper understanding of Sjögren’s Syndrome and reinforce the need for multidisciplinary management to address both systemic and oral health complications in these patients. Full article
(This article belongs to the Special Issue Updates in the Diagnosis and Management of Autoimmune Diseases)
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10 pages, 1348 KiB  
Brief Report
Urine Extracellular Vesicles Size Subsets as Lupus Nephritis Biomarkers
by Itze C. Navarro-Hernandez, Raúl F. Reyes-Huerta, Mariana Cañez-Hernández, Jiram Torres-Ruiz, Daniel A. Carrillo-Vázquez, Laura P. Whittall-García, David E. Meza-Sánchez, Guillermo Juárez-Vega, Diana Gómez-Martin, José M. Hernández-Hernández and José L. Maravillas-Montero
Diagnostics 2024, 14(20), 2271; https://doi.org/10.3390/diagnostics14202271 - 12 Oct 2024
Viewed by 681
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disorder that often leads to kidney injury, known as lupus nephritis (LN). Although renal biopsy is the primary way to diagnose LN, it is invasive and not practical for regular monitoring. As an alternative, several groups [...] Read more.
Systemic lupus erythematosus (SLE) is an autoimmune disorder that often leads to kidney injury, known as lupus nephritis (LN). Although renal biopsy is the primary way to diagnose LN, it is invasive and not practical for regular monitoring. As an alternative, several groups have proposed urinary extracellular vesicles (uEVs) as potential biomarkers for LN, as recent studies have shown their significance in reflecting kidney-related diseases. As a result, we developed a flow cytometry approach that allowed us to determine that LN patients exhibited a significantly higher total uEV concentration compared to SLE patients without kidney involvement. Additionally, an analysis of different-sized uEV subsets revealed that microvesicles ranging from 0.3 to 0.5 μm showed the most promise for distinguishing LN. These findings indicate that evaluating uEV concentration and size distribution could be a valuable diagnostic and monitoring tool for LN, pending further validation in more comprehensive studies. Full article
(This article belongs to the Special Issue Updates in the Diagnosis and Management of Autoimmune Diseases)
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