Diagnosis of Pancreatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 760

Special Issue Editor


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Guest Editor
Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Interests: pancreatic disease; endoscopy; clinical epidemiology

Special Issue Information

Dear Colleagues,

The pancreas, a vital organ in the human body, plays a regulatory role in both the digestive and endocrine systems. Pancreatic diseases include diabetes mellitus, exocrine pancreatic insufficiency, cystic fibrosis, pseudocysts, cysts, congenital malformations, pancreatic cancer, etc. The pancreas has a special anatomical location in the human body, adjacent to major organs and blood vessels such as the liver, duodenum, stomach, and spleen, which makes local treatment methods such as surgery and radiotherapy very difficult. Therefore, the early diagnosis of these diseases is critical for effective treatment and improved patient outcomes. However, pancreatic cancer often has an insidious onset and non-specific clinical manifestations, making early diagnosis even more difficult.

In this Special Issue, we aim to highlight the latest diagnostic techniques and advances in imaging technology, biomarkers, and genetic testing that enhance the accuracy and timeliness of pancreatic disease diagnosis. We are looking forward to accepting original research and review articles dealing with these and related areas. We hope to promote the development of the diagnostic level of pancreatic diseases through the efforts of researchers and clinicians, so that patients can achieve a better prognosis and quality of life.

Prof. Dr. Dong Wu
Guest Editor

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Keywords

  • pancreatic cancer
  • pancreatitis
  • biomarkers
  • imaging
  • early detection
  • diagnosis
  • outcomes

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Published Papers (1 paper)

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Research

14 pages, 2245 KiB  
Article
Clinical Feasibility of 5.0 T MRI/MRCP in Characterizing Pancreatic Cystic Lesions: Comparison with 3.0 T and MDCT
by Huijia Zhao, Qiang Xu, Ruichen Gao, Bohui Yin, Gan Sun, Ke Xue, Yuxin Yang, Enhui Li, Liang Zhu, Feng Feng and Wenming Wu
Diagnostics 2024, 14(21), 2457; https://doi.org/10.3390/diagnostics14212457 - 2 Nov 2024
Viewed by 486
Abstract
Objectives: To assess the feasibility of 5.0 T magnetic resonance imaging (MRI) in characterizing pancreatic cystic lesions (PCLs), compared with 3.0 T MRI and multidetector computed tomography (MDCT). Methods: Thirty-five patients with PCLs underwent 5.0 T MR alongside 3.0 T MR or MDCT. [...] Read more.
Objectives: To assess the feasibility of 5.0 T magnetic resonance imaging (MRI) in characterizing pancreatic cystic lesions (PCLs), compared with 3.0 T MRI and multidetector computed tomography (MDCT). Methods: Thirty-five patients with PCLs underwent 5.0 T MR alongside 3.0 T MR or MDCT. Two observers measured subjective and objective image quality scores. The consistency of two observers between 5.0 T and 3.0 T was calculated by intraclass correlation coefficients. The characteristics of PCLs and their specific diagnosis, as well as benignity/malignancy, were evaluated across MDCT, 3.0 T, and 5.0 T MRI. Results: The 5.0 T MR demonstrated significantly higher subjective image quality and SNR on T1WI compared to that in 3.0 T MR (p < 0.05). The 5.0 T MRI identified more cyst lesions than the 3.0 T MRI (40 and 32) and MDCT (82 and 56). The sensitivity, specificity, and accuracy for differentiating benign from malignant lesions with 5.0 T MRI (75%, 100%, and 91.4%, respectively) surpassed those of 3.0 T MRI and MDCT. The accuracy of the specific diagnosis of PCLs at 5.0 T MRI (80%) was superior to 3.0 T MRI and MDCT. Conclusions: 5.0 T MRI exhibits certain superiority in delineating details of PCLs and in clinical diagnostic accuracy, outperforming MDCT and 3.0 T MRI while maintaining sufficient image quality. Full article
(This article belongs to the Special Issue Diagnosis of Pancreatic Diseases)
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