Advancements in Hematopathology Diagnostic Techniques

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1852

Special Issue Editor


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Guest Editor
Hematology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Interests: hematology; chronic lymphocytic leukemia; immunophenotyping; leukemia

Special Issue Information

Dear Colleagues,

In recent years, the field of hematopathology has experienced significant progress in novel diagnostic techniques. These include immunohistochemistry, flow cytometry, advanced molecular techniques, and next-generation sequencing. These techniques have revolutionized the diagnosis, risk stratification, and monitoring of hematologic malignancies (minimal residual disease) leading to more accurate and personalized treatment options, including target drugs. The recently updated WHO classification of hematological malignancies is based on integrating these techniques (integrated diagnostic).

Moreover, the incorporation of these diagnostic techniques with artificial intelligence and machine learning algorithms exhibits significant potential for enhancing the efficiency and precision of hematopathology diagnosis. These technologies can assist pathologists in automating data analysis and interpretation, resulting in accelerated and more precise diagnosis. Continued advancements in technology, diagnostic techniques and understanding of hematologic diseases are expected to further enhance the accuracy and efficiency of diagnosis. Moreover, the integration of multidimensional datasets, such as genomics, proteomics, phenotypic and clinical data, will enable a more comprehensive characterization of hematologic diseases. The generation of these algorithms could also in predict the response to different treatment options in the future.

The primary objective of this Special Issue is to offer valuable insights into the contemporary advancements and practical utilization of diagnostic techniques in hematopathology. Additionally, we aim to discuss the future prospects of these techniques, emphasizing the need for ongoing research and development to improve patient outcomes in hematologic malignancies.

Dr. José Antonio García-Vela
Guest Editor

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Keywords

  • hematopathology
  • flow cytometry
  • next generation sequencing (NGS)
  • minimal residual disease (MRD)
  • machine learning algorithms

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Published Papers (1 paper)

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Review

20 pages, 2268 KiB  
Review
Comparative Review of the Current and Future Strategies to Evaluate Bone Marrow Infiltration at Diffuse Large B-Cell Lymphoma Diagnosis
by Fernando Martin-Moro, Javier Lopez-Jimenez, Jose A. Garcia-Marco and Jose A. Garcia-Vela
Diagnostics 2024, 14(6), 658; https://doi.org/10.3390/diagnostics14060658 - 21 Mar 2024
Cited by 1 | Viewed by 1345
Abstract
Diffuse large B-cell lymphoma (DLBCL) requires a complete staging at diagnosis that may have prognostic and therapeutic implications. The role of bone marrow (BM) biopsy (BMB) is controversial in the era of nuclear imaging techniques. We performed a comparative review of 25 studies [...] Read more.
Diffuse large B-cell lymphoma (DLBCL) requires a complete staging at diagnosis that may have prognostic and therapeutic implications. The role of bone marrow (BM) biopsy (BMB) is controversial in the era of nuclear imaging techniques. We performed a comparative review of 25 studies focused on BM evaluation at DLBCL diagnosis, including at least two of the following techniques: BMB, flow cytometry, and positron emission tomography (PET-FDG). The report about BM involvement (BMi), diagnostic accuracy, and prognostic significance was collected and compared among techniques. A concordance analysis between BMB, FCM, and PET was also performed, and we deeply evaluated the implications of the different types of BMi: concordant by LBCL or discordant by low-grade B-cell lymphoma for both BMB and FCM, and focal or diffuse uptake pattern for PET. As a main conclusion, BMB, FCM, and PET are complementary tools that provide different and clinically relevant information in the assessment of BMi in newly diagnosed DLBCL. Full article
(This article belongs to the Special Issue Advancements in Hematopathology Diagnostic Techniques)
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