Diagnosis and Prognosis of Inflammatory Bowel Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 4515

Special Issue Editor


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Guest Editor
Department of Gastroenterology, Dietetics and Internal Diseases, University of Medical Sciences Poznan, Przybyszewskiego 49, 60-355 Poznan, Poland
Interests: gastroenterology; human nutrition; internal diseases; inflammatory bowel diseases

Special Issue Information

Dear Colleagues,

Inflammatory Bowel Diseases (IBD) is a non-specific inflammatory disease of the intestine with unknown etiology, including Crohn's Disease (CD) and Ulcerative Colitis (UC). Both of these diseases involve intestinal inflammation and the disruption of the mucosal barrier, leading to symptoms such as diarrhea, abdominal pain, and bloody stools.

The most accurate method for diagnosing IBD is colonoscopy, which can help in observing the inflammation and the lesion site of the intestinal mucosa. In addition, auxiliary examinations such as blood tests, X-rays, and CTs can also help diagnose the disease. During the diagnosis process, doctors will comprehensively consider the patient's symptoms, signs, and examination results to make an accurate diagnosis.

Although the pathogenesis of IBD is still not fully understood, studies have identified some possible risk factors, such as genetic factors, immune factors, environmental factors, etc. In the future, we need to further deepen our understanding of the pathogenesis of IBD, providing more effective means for the early diagnosis and prognosis of the disease.

Dr. Liliana Łykowska-Szuber
Guest Editor

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Keywords

  • inflammatory bowel disease
  • tuberculosis
  • acute pancreatitis
  • chronic pancreatitis
  • celiac disease
  • biliary disease
  • gall bladder diseases
  • pancreatic cancer
  • colon cancer
  • diverticulitis
  • gastrointestinal infections
  • esophageal cancer
  • Barrett esophagus

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Published Papers (2 papers)

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18 pages, 837 KiB  
Review
A Comprehensive Multidisciplinary Approach to Diagnosing Chronic Inflammatory Bowel Diseases: Integration of Clinical, Endoscopic, and Imaging Modalities
by Clelia Cicerone, Ferdinando D’Amico, Mariangela Allocca, Alessandra Zilli, Tommaso Lorenzo Parigi, Silvio Danese and Federica Furfaro
Diagnostics 2024, 14(14), 1530; https://doi.org/10.3390/diagnostics14141530 - 16 Jul 2024
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Abstract
Chronic inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, present diagnostic challenges due to their complex and heterogeneous nature. While histology remains fundamental for accurate diagnosis, a multidisciplinary approach incorporating clinical, endoscopic, and imaging modalities is increasingly recognized as essential for [...] Read more.
Chronic inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, present diagnostic challenges due to their complex and heterogeneous nature. While histology remains fundamental for accurate diagnosis, a multidisciplinary approach incorporating clinical, endoscopic, and imaging modalities is increasingly recognized as essential for comprehensive evaluation. This article delves into the importance of integrating various diagnostic techniques in the assessment of IBD. Colonoscopy and histology, with its ability to directly visualize the intestinal mucosa, play a central role in the diagnostic process. However, histological analysis alone may not suffice, necessitating the inclusion of advanced imaging techniques, such as magnetic resonance enterography (MRE), computed tomography enterography (CTE), and intestinal ultrasound (IUS). These techniques provide valuable insights into the disease’s extent, severity, and complications, and should be used in conjunction with biochemical parameters. These modalities complement traditional endoscopic and histological findings, offering a more holistic understanding of the disease process. A multidisciplinary approach that incorporates clinical, endoscopic, histological, serological, and imaging assessments enables clinicians to achieve a more accurate and timely diagnosis of IBD. Moreover, this integrated approach facilitates personalized treatment strategies tailored to individual patient needs, ultimately improving clinical outcomes and quality of life for those affected by chronic inflammatory bowel diseases. Full article
(This article belongs to the Special Issue Diagnosis and Prognosis of Inflammatory Bowel Diseases)
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17 pages, 1771 KiB  
Systematic Review
Unraveling the Interplay of KRAS, NRAS, BRAF, and Micro-Satellite Instability in Non-Metastatic Colon Cancer: A Systematic Review
by Elena Orlandi, Mario Giuffrida, Serena Trubini, Enrico Luzietti, Massimo Ambroggi, Elisa Anselmi, Patrizio Capelli and Andrea Romboli
Diagnostics 2024, 14(10), 1001; https://doi.org/10.3390/diagnostics14101001 - 12 May 2024
Cited by 2 | Viewed by 2257
Abstract
Microsatellite Instability (MSI-H) occurs in approximately 15% of non-metastatic colon cancers, influencing patient outcomes positively compared to microsatellite stable (MSS) cancers. This systematic review focuses on the prognostic significance of KRAS, NRAS, and BRAF mutations within MSI-H colon cancer. Through comprehensive searches in [...] Read more.
Microsatellite Instability (MSI-H) occurs in approximately 15% of non-metastatic colon cancers, influencing patient outcomes positively compared to microsatellite stable (MSS) cancers. This systematic review focuses on the prognostic significance of KRAS, NRAS, and BRAF mutations within MSI-H colon cancer. Through comprehensive searches in databases like MEDLINE, EMBASE, and others until 1 January 2024, we selected 8 pertinent studies from an initial pool of 1918. These studies, encompassing nine trials and five observational studies involving 13,273 patients, provided insights into disease-free survival (DFS), survival after recurrence, and overall survival. The pooled data suggest that while KRAS and BRAF mutations typically predict poorer outcomes in MSS colorectal cancer, their impact is less pronounced in MSI contexts, with implications varying across different stages of cancer and treatment responses. In particular, adverse effects of these mutations manifest significantly upon recurrence rather than affecting immediate DFS. Our findings confirm the complex interplay between genetic mutations and MSI status, emphasizing the nuanced role of MSI in modifying the prognostic implications of KRAS, NRAS, and BRAF mutations in colon cancer. This review underscores the importance of considering MSI alongside mutational status in the clinical decision-making process, aiming to tailor therapeutic strategies more effectively for colon cancer patients. Full article
(This article belongs to the Special Issue Diagnosis and Prognosis of Inflammatory Bowel Diseases)
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